{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao Z"],"funding":["National Key R&amp;amp;D Project of China","Natural Science Foundation of Fujian Province, China","National Natural Science Foundation of China","National Key R&D Project of China","Doctoral Innovation Team from Shangluo, China"],"pagination":["E958"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6413133"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(4)"],"pubmed_abstract":["Pre-mRNA cleavage and polyadenylation is an essential step for almost all mRNA in eukaryotes. The <i>cis</i>-elements around the poly(A) sites, however, are very diverse among different organisms. We characterized the poly(A) signals of seven different species, and compared them with that of four well-studied organisms. We found that ciliates do not show any dominant poly(A) signal; a triplet (UAA) and tetramers (UAAA and GUAA) are dominant in diatoms and red alga, respectively; and green alga <i>Ostreococcus</i> uses UGUAA as its poly(A) signal. Spikemoss and moss use conserved AAUAAA signals that are similar to other land plants. Our analysis suggests that the first two bases (NN in NNUAAA) are likely degenerated whereas UAAA appears to be the core motif. Combined with other published re"],"journal":["International journal of molecular sciences"],"pubmed_title":["Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal."],"pmcid":["PMC6413133"],"funding_grant_id":["2016YFE0108800","61871463","2017J01068","SK2017-45","61573296"],"pubmed_authors":["Liang C","Ji G","Li QQ","Zhao Z","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal.","description":"Pre-mRNA cleavage and polyadenylation is an essential step for almost all mRNA in eukaryotes. The <i>cis</i>-elements around the poly(A) sites, however, are very diverse among different organisms. We characterized the poly(A) signals of seven different species, and compared them with that of four well-studied organisms. We found that ciliates do not show any dominant poly(A) signal; a triplet (UAA) and tetramers (UAAA and GUAA) are dominant in diatoms and red alga, respectively; and green alga <i>Ostreococcus</i> uses UGUAA as its poly(A) signal. Spikemoss and moss use conserved AAUAAA signals that are similar to other land plants. Our analysis suggests that the first two bases (NN in NNUAAA) are likely degenerated whereas UAAA appears to be the core motif. Combined with other published re","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-07-12T03:24:09.724Z","creation":"2026-07-12T03:12:02.976Z"},"accession":"S-EPMC6413133","cross_references":{"pubmed":["30813258"],"doi":["10.3390/ijms20040958"]}}