{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Manners O"],"funding":["Worldwide Cancer Research","Medical Research Council","Biotechnology and Biological Sciences Research Council"],"pagination":["370-381"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6414752"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1862(3)"],"pubmed_abstract":["N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is a highly pervasive and dynamic modification found on eukaryotic RNA. Despite the failure to comprehend the true regulatory potential of this epitranscriptomic mark for decades, our knowledge of m<sup>6</sup>A has rapidly expanded in recent years. The modification has now been functionally linked to all stages of mRNA metabolism and demonstrated to regulate a variety of biological processes. Furthermore, m<sup>6</sup>A has been identified on transcripts encoded by a wide range of viruses. Studies to investigate m<sup>6</sup>A function in viral-host interactions have highlighted distinct roles indicating widespread regulatory control over viral life cycles. As a result, unveiling the true influence of m<sup>6</sup>A modification could revolut"],"journal":["Biochimica et biophysica acta. Gene regulatory mechanisms"],"pubmed_title":["m<sup>6</sup>A: Widespread regulatory control in virus replication."],"pmcid":["PMC6414752"],"funding_grant_id":["BB/M006557/1","16-1025","1942169","MR/R010145/1","95505168"],"pubmed_authors":["Whitehouse A","Baquero-Perez B","Manners O"],"additional_accession":[]},"is_claimable":false,"name":"m<sup>6</sup>A: Widespread regulatory control in virus replication.","description":"N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is a highly pervasive and dynamic modification found on eukaryotic RNA. Despite the failure to comprehend the true regulatory potential of this epitranscriptomic mark for decades, our knowledge of m<sup>6</sup>A has rapidly expanded in recent years. The modification has now been functionally linked to all stages of mRNA metabolism and demonstrated to regulate a variety of biological processes. Furthermore, m<sup>6</sup>A has been identified on transcripts encoded by a wide range of viruses. Studies to investigate m<sup>6</sup>A function in viral-host interactions have highlighted distinct roles indicating widespread regulatory control over viral life cycles. As a result, unveiling the true influence of m<sup>6</sup>A modification could revolut","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-05-31T22:56:49.892Z","creation":"2025-05-31T22:56:49.892Z"},"accession":"S-EPMC6414752","cross_references":{"pubmed":["30412798"],"doi":["10.1016/j.bbagrm.2018.10.015"]}}