biostudies-literatureManners OWorldwide Cancer ResearchMedical Research CouncilBiotechnology and Biological Sciences Research Council370-381https://www.ebi.ac.uk/biostudies/studies/S-EPMC6414752biostudies-literatureUnknown1862(3)N⁶-methyladenosine (m⁶A) is a highly pervasive and dynamic modification found on eukaryotic RNA. Despite the failure to comprehend the true regulatory potential of this epitranscriptomic mark for decades, our knowledge of m⁶A has rapidly expanded in recent years. The modification has now been functionally linked to all stages of mRNA metabolism and demonstrated to regulate a variety of biological processes. Furthermore, m⁶A has been identified on transcripts encoded by a wide range of viruses. Studies to investigate m⁶A function in viral-host interactions have highlighted distinct roles indicating widespread regulatory control over viral life cycles. As a result, unveiling the true influence of m⁶A modification could revolutBiochimica et biophysica acta. Gene regulatory mechanismsm⁶A: Widespread regulatory control in virus replication.PMC6414752BB/M006557/116-10251942169MR/R010145/195505168Whitehouse ABaquero-Perez BManners Ofalsem⁶A: Widespread regulatory control in virus replication.N⁶-methyladenosine (m⁶A) is a highly pervasive and dynamic modification found on eukaryotic RNA. Despite the failure to comprehend the true regulatory potential of this epitranscriptomic mark for decades, our knowledge of m⁶A has rapidly expanded in recent years. The modification has now been functionally linked to all stages of mRNA metabolism and demonstrated to regulate a variety of biological processes. Furthermore, m⁶A has been identified on transcripts encoded by a wide range of viruses. Studies to investigate m⁶A function in viral-host interactions have highlighted distinct roles indicating widespread regulatory control over viral life cycles. As a result, unveiling the true influence of m⁶A modification could revolut2019-01-01T00:00:00Z2019 Mar2025-05-31T22:56:49.892Z2025-05-31T22:56:49.892ZS-EPMC64147523041279810.1016/j.bbagrm.2018.10.015