{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":53,"searchCount":0},"additional":{"submitter":["Schrack JA"],"funding":["NIA NIH HHS","National Institutes of Health","National Institute on Aging"],"pagination":["560-567"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6417447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(4)"],"pubmed_abstract":["<h4>Background</h4>With aging, daily physical activity (PA) becomes less frequent and more fragmented. Accumulation patterns of daily PA-including transitions from active-to-sedentary behaviors-may provide important insights into functional status in older, less active populations.<h4>Methods</h4>Participants of the Baltimore Longitudinal Study of Aging (n = 680, 50% male, aged 27-94 years) completed a clinical assessment and wore an Actiheart accelerometer. Transitions between active and sedentary states were modeled as a probability (Active-to-Sedentary Transition Probability [ASTP]) defined as the reciprocal of the average PA bout duration. Cross-sectional associations between ASTP and gait speed (m/s), fatigability (rating-of-perceived-exertion [RPE]), 400 m time (seconds), and expanded short physical performance battery score were modeled using linear and logistic regression, adjusted for chronic conditions. Further analyses explored the utility of ASTP over-and-above total daily PA.<h4>Results</h4>In continuous models, each 0.10-unit higher ASTP was associated slower gait (β = -0.06 m/s, SE = 0.01), higher fatigability (β = 0.60 RPE, SE = 0.12), slower 400 m time (β = 16.31 s, SE = 2.70), and lower functioning (β = -0.13 expanded short physical performance battery score, SE = 0.03; p < .001). In categorical analyses, those in the highest tertile of ASTP were >2 times more likely to have high fatigability (rating of perceived exertion ≥10), slow 400 m time (>300 seconds) and reduced functional performance (expanded short physical performance battery score < 3.07) than those in the lowest tertile (p < .01). Further analyses demonstrated ASTP provided additional insight into functional outcomes beyond total daily PA.<h4>Conclusion</h4>Fragmented daily PA-as measured by ASTP-is strongly linked with measures of health and functional status and may identify those at risk of high fatigability and reduced functional performance over and above traditional PA metrics."],"journal":["The journals of gerontology. Series A, Biological sciences and medical sciences"],"pubmed_title":["Active-to-Sedentary Behavior Transitions, Fatigability, and Physical Functioning in Older Adults."],"pmcid":["PMC6417447"],"funding_grant_id":["U01AG057545","R01 AG050507","T32 AG000247","P30 AG021334","R21 AG053198","R01AG050507","U01 AG057545","R21AG053198","P30AG021334"],"pubmed_authors":["Simonsick EM","Ferrucci L","Kuo PL","Wanigatunga AA","Schrack JA","Zipunnikov V","Di J","Spira AP"],"view_count":["53"],"additional_accession":[]},"is_claimable":false,"name":"Active-to-Sedentary Behavior Transitions, Fatigability, and Physical Functioning in Older Adults.","description":"<h4>Background</h4>With aging, daily physical activity (PA) becomes less frequent and more fragmented. Accumulation patterns of daily PA-including transitions from active-to-sedentary behaviors-may provide important insights into functional status in older, less active populations.<h4>Methods</h4>Participants of the Baltimore Longitudinal Study of Aging (n = 680, 50% male, aged 27-94 years) completed a clinical assessment and wore an Actiheart accelerometer. Transitions between active and sedentary states were modeled as a probability (Active-to-Sedentary Transition Probability [ASTP]) defined as the reciprocal of the average PA bout duration. Cross-sectional associations between ASTP and gait speed (m/s), fatigability (rating-of-perceived-exertion [RPE]), 400 m time (seconds), and expanded short physical performance battery score were modeled using linear and logistic regression, adjusted for chronic conditions. Further analyses explored the utility of ASTP over-and-above total daily PA.<h4>Results</h4>In continuous models, each 0.10-unit higher ASTP was associated slower gait (β = -0.06 m/s, SE = 0.01), higher fatigability (β = 0.60 RPE, SE = 0.12), slower 400 m time (β = 16.31 s, SE = 2.70), and lower functioning (β = -0.13 expanded short physical performance battery score, SE = 0.03; p < .001). In categorical analyses, those in the highest tertile of ASTP were >2 times more likely to have high fatigability (rating of perceived exertion ≥10), slow 400 m time (>300 seconds) and reduced functional performance (expanded short physical performance battery score < 3.07) than those in the lowest tertile (p < .01). Further analyses demonstrated ASTP provided additional insight into functional outcomes beyond total daily PA.<h4>Conclusion</h4>Fragmented daily PA-as measured by ASTP-is strongly linked with measures of health and functional status and may identify those at risk of high fatigability and reduced functional performance over and above traditional PA metrics.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2024-02-14T23:42:02.57Z","creation":"2019-11-05T08:04:30Z"},"accession":"S-EPMC6417447","cross_references":{"pubmed":["30357322"],"doi":["10.1093/gerona/gly243"]}}