{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Derkach K"],"funding":["Russian Science Foundation"],"pagination":["e0213779"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6417728"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(3)"],"pubmed_abstract":["In diet-induced obesity, metformin (MF) has weight-lowering effect and improves glucose homeostasis and insulin sensitivity. However, there is no information on the efficiency of MF and the mechanisms of its action in melanocortin-type obesity. We studied the effect of the 10-day treatment with MF at the doses of 200, 400 and 600 mg/kg/day on the food intake and the metabolic and hormonal parameters in female C57Bl/6J (genotype Ay/a) agouti-mice with melanocortin-type obesity, and the influence of MF on the hypothalamic signaling in obese animals at the most effective metabolic dose (600 mg/kg/day). MF treatment led to a decrease in food intake, the body and fat weights, the plasma levels of glucose, insulin and leptin, all increased in agouti-mice, to an improvement of the lipid profile a"],"journal":["PloS one"],"pubmed_title":["The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect."],"pmcid":["PMC6417728"],"funding_grant_id":["16-15-10388"],"pubmed_authors":["Derkach K","Romanova I","Bakhtyukov A","Zakharova I","Zorina I","Bayunova L","Shpakov A"],"additional_accession":[]},"is_claimable":false,"name":"The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect.","description":"In diet-induced obesity, metformin (MF) has weight-lowering effect and improves glucose homeostasis and insulin sensitivity. However, there is no information on the efficiency of MF and the mechanisms of its action in melanocortin-type obesity. We studied the effect of the 10-day treatment with MF at the doses of 200, 400 and 600 mg/kg/day on the food intake and the metabolic and hormonal parameters in female C57Bl/6J (genotype Ay/a) agouti-mice with melanocortin-type obesity, and the influence of MF on the hypothalamic signaling in obese animals at the most effective metabolic dose (600 mg/kg/day). MF treatment led to a decrease in food intake, the body and fat weights, the plasma levels of glucose, insulin and leptin, all increased in agouti-mice, to an improvement of the lipid profile a","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-05-07T10:09:08.43Z","creation":"2026-04-07T22:46:56.262Z"},"accession":"S-EPMC6417728","cross_references":{"pubmed":["30870482"],"doi":["10.1371/journal.pone.0213779"]}}