{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu X"],"funding":["Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China","Science and Technology Commission of Shanghai Municipality, China","Shanghai Municipal Commission of Health and Family Planning, China"],"pagination":["497-504"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6422475"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(4)"],"pubmed_abstract":["<h4>Objective</h4>Angiogenesis is one of the key processes in the development of malignant tumors. The vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) signaling pathway regulates branching angiogenesis in cancer. In this study, we analyzed the associations of VEGF/VEGFR-2 proteins and VEGFR-2 genetic variations with the prognosis of gastric cancer (GC).<h4>Method</h4>We collected the clinical information of patients with GC and extracted genomic DNA from paraffin-embedded tissues. Immunohistochemical methods were used to detect the expression of VEGF and VEGFR-2 in GC tissues. Four single nucleotide polymorphisms of VEGFR-2 were detected by the TaqMan assay. The Kaplan-Meier method and Cox regression model were applied to analyze the associations between clinicopath"],"journal":["Cancer biology & therapy"],"pubmed_title":["The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer."],"pmcid":["PMC6422475"],"funding_grant_id":["Grant No.15ZR1427700","Grant No.15LC05 and No. 13YJ22","Grant No. 201540271"],"pubmed_authors":["Xue W","Wang R","Zheng L","Zhu X","Zhu ML","Wang Y","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer.","description":"<h4>Objective</h4>Angiogenesis is one of the key processes in the development of malignant tumors. The vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) signaling pathway regulates branching angiogenesis in cancer. In this study, we analyzed the associations of VEGF/VEGFR-2 proteins and VEGFR-2 genetic variations with the prognosis of gastric cancer (GC).<h4>Method</h4>We collected the clinical information of patients with GC and extracted genomic DNA from paraffin-embedded tissues. Immunohistochemical methods were used to detect the expression of VEGF and VEGFR-2 in GC tissues. Four single nucleotide polymorphisms of VEGFR-2 were detected by the TaqMan assay. The Kaplan-Meier method and Cox regression model were applied to analyze the associations between clinicopath","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-04-08T03:16:55.844Z","creation":"2019-11-07T08:03:20Z"},"accession":"S-EPMC6422475","cross_references":{"pubmed":["30380970"],"doi":["10.1080/15384047.2018.1537575"]}}