{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang P"],"funding":["U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","United States Department of Defense | Defense Advanced Research Projects Agency","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)","NIH HHS"],"pagination":["4808"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6423036"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["In addition to the characteristic motor symptoms, Parkinson's disease (PD) often involves a constellation of sleep and mood symptoms. However, the mechanisms underlying these comorbidities are largely unknown. We have previously reconstructed gene networks in the striatum of a population of (C57BL/6J x A/J) F2 mice and associated the networks to sleep and affective phenotypes, providing a resource for integrated analyses to investigate perturbed sleep and affective functions at the gene network level. Combining this resource with PD-relevant transcriptomic datasets from humans and mice, we identified four networks that showed elevated gene expression in PD patients, including a circadian clock and mitotic network that was altered similarly in mouse models of PD. We then utilized multiple t"],"journal":["Scientific reports"],"pubmed_title":["Parkinson's Disease is Associated with Dysregulations of a Dopamine-Modulated Gene Network Relevant to Sleep and Affective Neurobehaviors in the Striatum."],"pmcid":["PMC6423036"],"funding_grant_id":["F30MH106293","W911NF-10-1006","S10 OD018522","T32HL007909"],"pubmed_authors":["Scarpa JR","Vitaterna MH","Gao VD","Kasarskis A","Turek FW","Jiang P"],"additional_accession":[]},"is_claimable":false,"name":"Parkinson's Disease is Associated with Dysregulations of a Dopamine-Modulated Gene Network Relevant to Sleep and Affective Neurobehaviors in the Striatum.","description":"In addition to the characteristic motor symptoms, Parkinson's disease (PD) often involves a constellation of sleep and mood symptoms. However, the mechanisms underlying these comorbidities are largely unknown. We have previously reconstructed gene networks in the striatum of a population of (C57BL/6J x A/J) F2 mice and associated the networks to sleep and affective phenotypes, providing a resource for integrated analyses to investigate perturbed sleep and affective functions at the gene network level. Combining this resource with PD-relevant transcriptomic datasets from humans and mice, we identified four networks that showed elevated gene expression in PD patients, including a circadian clock and mitotic network that was altered similarly in mouse models of PD. We then utilized multiple t","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2026-05-05T03:41:39.187Z","creation":"2019-06-06T21:00:31Z"},"accession":"S-EPMC6423036","cross_references":{"pubmed":["30886221"],"doi":["10.1038/s41598-019-41248-4"]}}