{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Jiang X"],"funding":["Deutsche Forschungsgemeinschaft"],"pubmed_abstract":["Type VI protein secretion systems (T6SSs) have been identified in many plant-associated bacteria. However, despite the fact that effector proteins may modulate host responses or interbacterial competition, only a few have been functionally dissected in detail. We dissected the T6SS in Azoarcus olearius strain BH72, a nitrogen-fixing model endophyte of grasses. The genome harbors two gene clusters encoding putative T6SSs, tss-1 and tss-2, of which only T6SS-2 shared genetic organization and functional homology with the H1-T6SS of Pseudomonas aeruginosa. While tss-2 genes were constitutively expressed, tss-1 genes were strongly up-regulated under conditions of nitrogen fixation. A comparative analysis of the wild type and mutants lacking either functional tss-1 or tss-2 allowed to differenti"],"journal":["Frontiers in microbiology"],"pagination":["459"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6423157"],"repository":["biostudies-literature"],"pubmed_title":["Two Functionally Deviating Type 6 Secretion Systems Occur in the Nitrogen-Fixing Endophyte Azoarcus olearius BH72."],"pmcid":["PMC6423157"],"pubmed_authors":["Jiang X","Dinse T","Herglotz J","Sappa PK","Reinhold-Hurek B","Volker U","Beust A"],"additional_accession":[]},"is_claimable":false,"name":"Two Functionally Deviating Type 6 Secretion Systems Occur in the Nitrogen-Fixing Endophyte Azoarcus olearius BH72.","description":"Type VI protein secretion systems (T6SSs) have been identified in many plant-associated bacteria. However, despite the fact that effector proteins may modulate host responses or interbacterial competition, only a few have been functionally dissected in detail. We dissected the T6SS in Azoarcus olearius strain BH72, a nitrogen-fixing model endophyte of grasses. The genome harbors two gene clusters encoding putative T6SSs, tss-1 and tss-2, of which only T6SS-2 shared genetic organization and functional homology with the H1-T6SS of Pseudomonas aeruginosa. While tss-2 genes were constitutively expressed, tss-1 genes were strongly up-regulated under conditions of nitrogen fixation. A comparative analysis of the wild type and mutants lacking either functional tss-1 or tss-2 allowed to differenti","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-04T11:08:10.62Z","creation":"2025-02-19T01:49:10.396Z"},"accession":"S-EPMC6423157","cross_references":{"pubmed":["30915056"],"doi":["10.3389/fmicb.2019.00459"]}}