{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tian X"],"funding":["NCI NIH HHS"],"pagination":["8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6423228"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3"],"pubmed_abstract":["The development of genetic engineering in the 1970s marked a new frontier in genome-editing technology. Gene-editing technologies have provided a plethora of benefits to the life sciences. The clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/ Cas9) system is a versatile technology that provides the ability to add or remove DNA in the genome in a sequence-specific manner. Serious efforts are underway to improve the efficiency of CRISPR/Cas9 targeting and thus reduce off-target effects. Currently, various applications of CRISPR/Cas9 are used in cancer biology and oncology to perform robust site-specific gene editing, thereby becoming more useful for biological and clinical applications. Many variants and applications of CRISPR/Cas9 are being rapid"],"journal":["NPJ precision oncology"],"pubmed_title":["CRISPR/Cas9 - An evolving biological tool kit for cancer biology and oncology."],"pmcid":["PMC6423228"],"funding_grant_id":["R01 CA166011","R01 CA187027","R01 CA196639"],"pubmed_authors":["Gu T","Lee MH","Tian X","Patel S","Dong Z","Bode AM"],"additional_accession":[]},"is_claimable":false,"name":"CRISPR/Cas9 - An evolving biological tool kit for cancer biology and oncology.","description":"The development of genetic engineering in the 1970s marked a new frontier in genome-editing technology. Gene-editing technologies have provided a plethora of benefits to the life sciences. The clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/ Cas9) system is a versatile technology that provides the ability to add or remove DNA in the genome in a sequence-specific manner. Serious efforts are underway to improve the efficiency of CRISPR/Cas9 targeting and thus reduce off-target effects. Currently, various applications of CRISPR/Cas9 are used in cancer biology and oncology to perform robust site-specific gene editing, thereby becoming more useful for biological and clinical applications. Many variants and applications of CRISPR/Cas9 are being rapid","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-05-29T20:27:18.943Z","creation":"2025-05-29T20:27:18.943Z"},"accession":"S-EPMC6423228","cross_references":{"pubmed":["30911676"],"doi":["10.1038/s41698-019-0080-7"]}}