{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu ZY"],"funding":["National Natural Science Foundation of China"],"pagination":["e23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6424848"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(3)"],"pubmed_abstract":["<h4>Objective</h4>There has been growing body of literatures showing that chronic inflammation might play an important role in cancer development. This meta-analysis aimed to assess the association between the dietary inflammation index (DII) score and gynecological cancers.<h4>Methods</h4>A systematic search of PubMed, EMBASE and Web of Science up until October 20, 2018 was carried out to retrieve all related cohort and case-control studies. The summary risk assessments were pooled using random-effects models. The dose-response relationship was estimated by linear relationship model.<h4>Results</h4>Twelve case-control studies (10,774 cases/15,958 controls) and six prospective cohort studies (330,363 participants/23,133 incident cases) were included in this meta-analysis. The pooled adjusted relative risk (RR) of gynecological cancers for the highest DII category compared to the lowest category was 1.38, (95% confidence intervals [CIs], 1.21-1.56, p<0.001]. A positive dose-response relationship was also noticed. Stratified by study design indicated that, the pooled RRs was significantly higher for case-control studies than cohort studies (p for interaction<0.001), for studies conducted among participants with body mass index (BMI) ≥25 kg/m² than participants with BMI <25 kg/m² (p for interaction=0.026), among participants with ovarian cancer and endometrial cancer than participants with breast cancer (p for interaction = 0.038). Meta-regression analysis further confirmed that study design significantly contributed to inter-study heterogeneity (p<0.001).<h4>Conclusion</h4>This meta-analysis suggests that elevated DII is independently associated with a higher risk of gynecological cancers, especially patients with ovarian cancer and endometrial cancer and among obese participants."],"journal":["Journal of gynecologic oncology"],"pubmed_title":["Dietary inflammatory index and risk of gynecological cancers: a systematic review and meta-analysis of observational studies."],"pmcid":["PMC6424848"],"funding_grant_id":["81602853"],"pubmed_authors":["Gao XP","Liu ZY","Liu YH","Wang LJ","Jing CX","Zeng FF","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Dietary inflammatory index and risk of gynecological cancers: a systematic review and meta-analysis of observational studies.","description":"<h4>Objective</h4>There has been growing body of literatures showing that chronic inflammation might play an important role in cancer development. This meta-analysis aimed to assess the association between the dietary inflammation index (DII) score and gynecological cancers.<h4>Methods</h4>A systematic search of PubMed, EMBASE and Web of Science up until October 20, 2018 was carried out to retrieve all related cohort and case-control studies. The summary risk assessments were pooled using random-effects models. The dose-response relationship was estimated by linear relationship model.<h4>Results</h4>Twelve case-control studies (10,774 cases/15,958 controls) and six prospective cohort studies (330,363 participants/23,133 incident cases) were included in this meta-analysis. The pooled adjusted relative risk (RR) of gynecological cancers for the highest DII category compared to the lowest category was 1.38, (95% confidence intervals [CIs], 1.21-1.56, p<0.001]. A positive dose-response relationship was also noticed. Stratified by study design indicated that, the pooled RRs was significantly higher for case-control studies than cohort studies (p for interaction<0.001), for studies conducted among participants with body mass index (BMI) ≥25 kg/m² than participants with BMI <25 kg/m² (p for interaction=0.026), among participants with ovarian cancer and endometrial cancer than participants with breast cancer (p for interaction = 0.038). Meta-regression analysis further confirmed that study design significantly contributed to inter-study heterogeneity (p<0.001).<h4>Conclusion</h4>This meta-analysis suggests that elevated DII is independently associated with a higher risk of gynecological cancers, especially patients with ovarian cancer and endometrial cancer and among obese participants.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-04T11:08:47.303Z","creation":"2019-06-06T22:54:18Z"},"accession":"S-EPMC6424848","cross_references":{"pubmed":["30887752"],"doi":["10.3802/jgo.2019.30.e23"]}}