{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(3)"],"submitter":["Chandel P"],"pubmed_abstract":["In the present work, coumarin based pyrazolines (<b>7a-g</b>) have been synthesized and investigated for their <i>in vitro</i> and <i>in vivo</i> anti-inflammatory potential. Amongst the synthesized compounds, compounds <b>7a</b>, <b>7d</b> and <b>7f</b> exhibited significant <i>in vitro</i> anti-inflammatory activity as compared to the standard etoricoxib. Keeping this in mind, <i>in vivo</i> investigations were carried out <i>via</i> carrageenan induced inflammation and acetic acid induced writhing models in male Wistar rats and compound <b>7a</b> was found to possess appreciable anti-inflammatory and analgesic potential. The mode of action of compound <b>7a</b> was also investigated by using substance P as the biomarker, which shows promising results. Further, the selectivity of the mos"],"journal":["MedChemComm"],"pagination":["421-430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6430084"],"repository":["biostudies-literature"],"pubmed_title":["Rationally synthesized coumarin based pyrazolines ameliorate carrageenan induced inflammation through COX-2/pro-inflammatory cytokine inhibition."],"pmcid":["PMC6430084"],"pubmed_authors":["Singla N","Singh G","Chandel P","Kumar A","Gill RK"],"additional_accession":[]},"is_claimable":false,"name":"Rationally synthesized coumarin based pyrazolines ameliorate carrageenan induced inflammation through COX-2/pro-inflammatory cytokine inhibition.","description":"In the present work, coumarin based pyrazolines (<b>7a-g</b>) have been synthesized and investigated for their <i>in vitro</i> and <i>in vivo</i> anti-inflammatory potential. Amongst the synthesized compounds, compounds <b>7a</b>, <b>7d</b> and <b>7f</b> exhibited significant <i>in vitro</i> anti-inflammatory activity as compared to the standard etoricoxib. Keeping this in mind, <i>in vivo</i> investigations were carried out <i>via</i> carrageenan induced inflammation and acetic acid induced writhing models in male Wistar rats and compound <b>7a</b> was found to possess appreciable anti-inflammatory and analgesic potential. The mode of action of compound <b>7a</b> was also investigated by using substance P as the biomarker, which shows promising results. Further, the selectivity of the mos","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2026-05-07T00:54:38.746Z","creation":"2021-02-19T17:56:48Z"},"accession":"S-EPMC6430084","cross_references":{"pubmed":["30996860"],"doi":["10.1039/c8md00457a"]}}