biostudies-literatureRodriguez-Emmenegger CHoward Hughes Medical InstituteNIGMS NIH HHS5376-5382https://www.ebi.ac.uk/biostudies/studies/S-EPMC6431222biostudies-literatureUnknown116(12)Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same periodic and quasiperiodic arrays were subsequently found in block copolymers, surfactants, lipids, glycolipids, and other complex molecules. Here we report the discovery of lamellar and hexagonal periodic arrays on the surface of vesicles generated from sequence-defined bicomponent monodisperse oligomers containing lipid and glycolipid mimics. These vesicles, known as glycodendrimersomes, act as cell-membrane mimics with hierarchical morphologies resembling bicomponent rafts. TheseProceedings of the National Academy of Sciences of the United States of AmericaEncoding biological recognition in a bicomponent cell-membrane mimic.PMC6431222R01 GM080279R01 GM097552Malhotra IPercec VKostina NYWilson CJSahoo DMoller MRodriguez-Emmenegger CXiao QReveron Perez AMKerzner MGoulian MLi SGood MCRahimi KSherman SEHan HBaumgart TKlein MLBuzzacchera IPartridge BEfalseEncoding biological recognition in a bicomponent cell-membrane mimic.Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same periodic and quasiperiodic arrays were subsequently found in block copolymers, surfactants, lipids, glycolipids, and other complex molecules. Here we report the discovery of lamellar and hexagonal periodic arrays on the surface of vesicles generated from sequence-defined bicomponent monodisperse oligomers containing lipid and glycolipid mimics. These vesicles, known as glycodendrimersomes, act as cell-membrane mimics with hierarchical morphologies resembling bicomponent rafts. These2019-01-01T00:00:00Z2019 Mar2026-07-17T00:07:26.06Z2026-07-12T03:12:06.021ZS-EPMC64312223081990010.1073/pnas.1821924116