{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Buettner CJ"],"funding":["National Cancer Institute","NCI NIH HHS"],"pagination":["5220-5226"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6432923"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(24)"],"pubmed_abstract":["While the influence of alkyl chain length and headgroup size on self-assembly behaviour has been well-established for simple surfactants, the rational control over the pH- and concentration-dependent self-assembly behaviour in stimuli responsive peptides remains an elusive goal. Here, we show that different amphiphilic peptides can have similar self-assembly phase diagrams, providing the relative strengths of the attractive and repulsive forces are balanced. Using palmitoyl-YYAAEEEEK(DO3A:Gd)-NH<sub>2</sub> and palmitoyl-YAAEEEEK(DO3A:Gd)-NH<sub>2</sub> as controls, we show that reducing hydrophobic attractive forces through fewer methylene groups in the alkyl chain will lead to a similar self-assembly phase diagram as increasing the electrostatic repulsive forces via the addition of a glu"],"journal":["Organic & biomolecular chemistry"],"pubmed_title":["Balancing the intermolecular forces in peptide amphiphiles for controlling self-assembly transitions."],"pmcid":["PMC6432923"],"funding_grant_id":["P30 CA016058","P30 CA013148","P30CA016058"],"pubmed_authors":["Ghosh A","Buettner CJ","Nicholl MJ","Tweedle MF","Goldberger JE","Ok S","Wallace AJ","Manos AA"],"additional_accession":[]},"is_claimable":false,"name":"Balancing the intermolecular forces in peptide amphiphiles for controlling self-assembly transitions.","description":"While the influence of alkyl chain length and headgroup size on self-assembly behaviour has been well-established for simple surfactants, the rational control over the pH- and concentration-dependent self-assembly behaviour in stimuli responsive peptides remains an elusive goal. Here, we show that different amphiphilic peptides can have similar self-assembly phase diagrams, providing the relative strengths of the attractive and repulsive forces are balanced. Using palmitoyl-YYAAEEEEK(DO3A:Gd)-NH<sub>2</sub> and palmitoyl-YAAEEEEK(DO3A:Gd)-NH<sub>2</sub> as controls, we show that reducing hydrophobic attractive forces through fewer methylene groups in the alkyl chain will lead to a similar self-assembly phase diagram as increasing the electrostatic repulsive forces via the addition of a glu","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-06-01T03:59:08.465Z","creation":"2025-06-01T03:59:08.465Z"},"accession":"S-EPMC6432923","cross_references":{"pubmed":["28594046"],"doi":["10.1039/c7ob00875a"]}}