{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Urrutia DN"],"funding":["Innova CORFO"],"pagination":["e0213032"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6437714"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(3)"],"pubmed_abstract":["Mesenchymal stem cells (MSCs) can trans/differentiate to neural precursors and/or mature neurons and promote neuroprotection and neurogenesis. The above could greatly benefit neurodegenerative disorders as well as in the treatment of post-traumatic and hereditary diseases of the central nervous system (CNS). In order to attain an ideal source of adult MSCs for the treatment of CNS diseases, adipose tissue, bone marrow, skin and umbilical cord derived MSCs were isolated and studied to explore differences with regard to neural differentiation capacity. In this study, we demonstrated that MSCs from several tissues can differentiate into neuron-like cells and differentially express progenitors and mature neural markers. Adipose tissue MSCs exhibited significantly higher expression of neural ma"],"journal":["PloS one"],"pubmed_title":["Comparative study of the neural differentiation capacity of mesenchymal stromal cells from different tissue sources: An approach for their use in neural regeneration therapies."],"pmcid":["PMC6437714"],"funding_grant_id":["13IEAT-20943 2013"],"pubmed_authors":["Mardones R","Minguell JJ","Caviedes P","Jofre CM","Urrutia DN","Vega-Letter AM"],"additional_accession":[]},"is_claimable":false,"name":"Comparative study of the neural differentiation capacity of mesenchymal stromal cells from different tissue sources: An approach for their use in neural regeneration therapies.","description":"Mesenchymal stem cells (MSCs) can trans/differentiate to neural precursors and/or mature neurons and promote neuroprotection and neurogenesis. The above could greatly benefit neurodegenerative disorders as well as in the treatment of post-traumatic and hereditary diseases of the central nervous system (CNS). In order to attain an ideal source of adult MSCs for the treatment of CNS diseases, adipose tissue, bone marrow, skin and umbilical cord derived MSCs were isolated and studied to explore differences with regard to neural differentiation capacity. In this study, we demonstrated that MSCs from several tissues can differentiate into neuron-like cells and differentially express progenitors and mature neural markers. Adipose tissue MSCs exhibited significantly higher expression of neural ma","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-05-07T03:29:18.367Z","creation":"2019-06-05T15:58:25Z"},"accession":"S-EPMC6437714","cross_references":{"pubmed":["30856179"],"doi":["10.1371/journal.pone.0213032"]}}