{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Logan LK"],"funding":["BLRD VA","NIAID NIH HHS"],"pagination":["595-599"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6440871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(6)"],"pubmed_abstract":["<h4>Background</h4>Fluoroquinolones are uncommonly prescribed in children, yet pediatric multidrug resistant (MDR) enterobacteriaceae (Ent) infections often reveal fluoroquinolone resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children.<h4>Methods</h4>A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children with third-generation cephalosporin-resistant and/or carbapenem-resistant Ent infections. Polymerase chain reaction and DNA analysis assessed bla and plasmid-mediated FQR (PMFQR) genes. Controls were children with third-generation cephalosporin, fluoroquinolone, and carbapenem-susceptible Ent infections matched by age, source and hospital. We assessed clinical-epidemiologic predictors of"],"journal":["The Pediatric infectious disease journal"],"pubmed_title":["Community Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children."],"pmcid":["PMC6440871"],"funding_grant_id":["R01 AI063517","R01 AI100560","K08 AI112506","R01 AI072219","I01 BX001974"],"pubmed_authors":["Konda S","Zheng X","Qureshi NK","Rispens JR","Marshall SH","Bonomo RA","Hujer AM","Rudin SD","Domitrovic TN","Logan LK","Weinstein RA","Hayden MK","Medernach RL"],"additional_accession":[]},"is_claimable":false,"name":"Community Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.","description":"<h4>Background</h4>Fluoroquinolones are uncommonly prescribed in children, yet pediatric multidrug resistant (MDR) enterobacteriaceae (Ent) infections often reveal fluoroquinolone resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children.<h4>Methods</h4>A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children with third-generation cephalosporin-resistant and/or carbapenem-resistant Ent infections. Polymerase chain reaction and DNA analysis assessed bla and plasmid-mediated FQR (PMFQR) genes. Controls were children with third-generation cephalosporin, fluoroquinolone, and carbapenem-susceptible Ent infections matched by age, source and hospital. We assessed clinical-epidemiologic predictors of","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-18T22:09:25.01Z","creation":"2020-06-04T07:02:31Z"},"accession":"S-EPMC6440871","cross_references":{"pubmed":["30281548"],"doi":["10.1097/INF.0000000000002205","10.1097/inf.0000000000002205"]}}