biostudies-literatureLogan LKBLRD VANIAID NIH HHS595-599https://www.ebi.ac.uk/biostudies/studies/S-EPMC6440871biostudies-literatureUnknown38(6)<h4>Background</h4>Fluoroquinolones are uncommonly prescribed in children, yet pediatric multidrug resistant (MDR) enterobacteriaceae (Ent) infections often reveal fluoroquinolone resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children.<h4>Methods</h4>A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children with third-generation cephalosporin-resistant and/or carbapenem-resistant Ent infections. Polymerase chain reaction and DNA analysis assessed bla and plasmid-mediated FQR (PMFQR) genes. Controls were children with third-generation cephalosporin, fluoroquinolone, and carbapenem-susceptible Ent infections matched by age, source and hospital. We assessed clinical-epidemiologic predictors ofThe Pediatric infectious disease journalCommunity Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.PMC6440871R01 AI063517R01 AI100560K08 AI112506R01 AI072219I01 BX001974Konda SZheng XQureshi NKRispens JRMarshall SHBonomo RAHujer AMRudin SDDomitrovic TNLogan LKWeinstein RAHayden MKMedernach RLfalseCommunity Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.<h4>Background</h4>Fluoroquinolones are uncommonly prescribed in children, yet pediatric multidrug resistant (MDR) enterobacteriaceae (Ent) infections often reveal fluoroquinolone resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children.<h4>Methods</h4>A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children with third-generation cephalosporin-resistant and/or carbapenem-resistant Ent infections. Polymerase chain reaction and DNA analysis assessed bla and plasmid-mediated FQR (PMFQR) genes. Controls were children with third-generation cephalosporin, fluoroquinolone, and carbapenem-susceptible Ent infections matched by age, source and hospital. We assessed clinical-epidemiologic predictors of2019-01-01T00:00:00Z2019 Jun2025-04-18T22:09:25.01Z2020-06-04T07:02:31ZS-EPMC64408713028154810.1097/INF.000000000000220510.1097/inf.0000000000002205