{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chang AM"],"funding":["NICHD NIH HHS","NCATS NIH HHS","NCCIH NIH HHS","NIA NIH HHS","NIDDK NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","NHLBI NIH HHS","NIMH NIH HHS","Medical Research Council","NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["5350"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6440993"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["The PERIOD2 (PER2) gene is a core molecular component of the circadian clock and plays an important role in the generation and maintenance of daily rhythms. Rs35333999, a missense variant of PER2 common in European populations, has been shown to associate with later chronotype. Chronotype relates to the timing of biological and behavioral activities, including when we sleep, eat, and exercise, and later chronotype is associated with longer intrinsic circadian period (cycle length), a fundamental property of the circadian system. Thus, we tested whether this PER2 variant was associated with circadian period and found significant associations with longer intrinsic circadian period as measured under forced desynchrony protocols, the 'gold standard' for intrinsic circadian period assessment. Minor allele (T) carriers exhibited significantly longer circadian periods when determinations were based on either core body temperature or plasma melatonin measurements, as compared to non-carriers (by 12 and 11 min, respectively; accounting for ~7% of inter-individual variance). These findings provide a possible underlying biological mechanism for inter-individual differences in chronotype, and support the central role of PER2 in the human circadian timing system."],"journal":["Scientific reports"],"pubmed_title":["Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans."],"pmcid":["PMC6440993"],"funding_grant_id":["R01 NS054277","R01 HL080978","UL1 TR001102","K01 HL136884","R01 GM105018","R21 HD086392","R01 DK105072","R01 HL093279","K24 HL105664","R21 HL121728","R01 HL140574","R21DK089378","K01 HL115458","F32 HL078360","R01 DK107859","F32 AG031690","T32 HL007901","P01 AG009975","F32 DK102323","R01 HL077399","R01 HL094654","R01 HL113338","R01 HL118601","R01 HL077453","R01 HL094806","R21 DK089378","R01 DK099512","R21 AT002571","R01 DK102696","R01 HL114088","R01 AG006072","R01 MH045130","MR/P012167/1"],"pubmed_authors":["Cain SW","Cohen DA","Saxena R","Buxton OM","Lane JM","Chang AM","Van Reen E","Rueger M","Duffy JF","Jones SE","Klerman EB","Frayling TM","Munch M","Bjonnes AC","Gooley JJ","Santhi N","Rajaratnam SMW","Scheuermaier K","Czeisler CA","Scheer FAJL","Rutter MK","Lockley SW","Weedon MN","Anderson C","Aeschbach D"],"additional_accession":[]},"is_claimable":false,"name":"Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans.","description":"The PERIOD2 (PER2) gene is a core molecular component of the circadian clock and plays an important role in the generation and maintenance of daily rhythms. Rs35333999, a missense variant of PER2 common in European populations, has been shown to associate with later chronotype. Chronotype relates to the timing of biological and behavioral activities, including when we sleep, eat, and exercise, and later chronotype is associated with longer intrinsic circadian period (cycle length), a fundamental property of the circadian system. Thus, we tested whether this PER2 variant was associated with circadian period and found significant associations with longer intrinsic circadian period as measured under forced desynchrony protocols, the 'gold standard' for intrinsic circadian period assessment. Minor allele (T) carriers exhibited significantly longer circadian periods when determinations were based on either core body temperature or plasma melatonin measurements, as compared to non-carriers (by 12 and 11 min, respectively; accounting for ~7% of inter-individual variance). These findings provide a possible underlying biological mechanism for inter-individual differences in chronotype, and support the central role of PER2 in the human circadian timing system.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2024-11-13T23:51:37.105Z","creation":"2019-06-06T21:04:10Z"},"accession":"S-EPMC6440993","cross_references":{"pubmed":["30926824"],"doi":["10.1038/s41598-019-41712-1"]}}