{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fatobene G"],"funding":["NHLBI NIH HHS","NCI NIH HHS"],"pagination":["835-843"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6442956"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["104(4)"],"pubmed_abstract":["We determined the incidence of disability related to chronic graft-<i>versus</i>-host disease (bronchiolitis obliterans, grade ≥2 keratoconjunctivitis sicca, sclerotic features or esophageal stricture) for three categories of alternative donor: cord blood, haplorelated marrow or peripheral blood with post-transplant cyclophosphamide, and unrelated single HLA-allele mismatched peripheral blood. Among 396 consecutive hematopoietic cell transplant recipients, 129 developed chronic graft-<i>versus</i>-host disease with 3-year cumulative incidences of 8% for cord blood, 24% for haplorelated grafts, and 55% for unrelated single HLA-allele mismatched peripheral blood. Disability rates were significantly lower for cord blood [hazard ratio (HR) 0.13; 95% confidence interval (CI): 0.1-0.4] and for the haplorelated group (HR 0.31; 95% CI: 0.1-0.7) compared to the rate in the group transplanted with unrelated single HLA-allele mismatched peripheral blood. Cord blood recipients were also >2-fold more likely to return to work/school within 3 years from the onset of chronic graft-<i>versus</i>-host disease (HR 2.54; 95% CI: 1.1-5.7, <i>P</i>=0.02), and the haplorelated group trended similarly (HR 2.38; 95% CI: 1.0-5.9, <i>P</i>=0.06). Cord blood recipients were more likely to discontinue immunosuppression than were recipients of unrelated single HLA-allele mismatched peripheral blood (HR 3.96; 95% CI: 1.9-8.4, <i>P</i>=0.0003), similarly to the haplorelated group (HR 4.93; 95% CI: 2.2-11.1, <i>P</i>=0.0001). Progression-free survival and non-relapse mortality did not differ between groups grafted from different types of donors. Our observations that, compared to recipients of unrelated single HLA-allele mismatched peripheral blood, recipients of cord blood and haplorelated grafts less often developed disability related to chronic graft-<i>versus</i>-host disease, and were more likely to resume work/school, should help better counseling of pre-hematopoietic cell transplant candidates."],"journal":["Haematologica"],"pubmed_title":["Disability related to chronic graft -<i>versus</i>-host disease after alternative donor hematopoietic cell transplantation."],"pmcid":["PMC6442956"],"funding_grant_id":["P30 CA015704","P01 CA018029","R01 CA118953","P01 HL122173","U01 CA118953"],"pubmed_authors":["Salit RB","Balgansuren G","Lee SJ","Martin PJ","Delaney C","Milano F","Storer BE","Fatobene G","Flowers ME","Carpenter PA","Sandmaier BM","Petersdorf EW","Cheng GS"],"additional_accession":[]},"is_claimable":false,"name":"Disability related to chronic graft -<i>versus</i>-host disease after alternative donor hematopoietic cell transplantation.","description":"We determined the incidence of disability related to chronic graft-<i>versus</i>-host disease (bronchiolitis obliterans, grade ≥2 keratoconjunctivitis sicca, sclerotic features or esophageal stricture) for three categories of alternative donor: cord blood, haplorelated marrow or peripheral blood with post-transplant cyclophosphamide, and unrelated single HLA-allele mismatched peripheral blood. Among 396 consecutive hematopoietic cell transplant recipients, 129 developed chronic graft-<i>versus</i>-host disease with 3-year cumulative incidences of 8% for cord blood, 24% for haplorelated grafts, and 55% for unrelated single HLA-allele mismatched peripheral blood. Disability rates were significantly lower for cord blood [hazard ratio (HR) 0.13; 95% confidence interval (CI): 0.1-0.4] and for the haplorelated group (HR 0.31; 95% CI: 0.1-0.7) compared to the rate in the group transplanted with unrelated single HLA-allele mismatched peripheral blood. Cord blood recipients were also >2-fold more likely to return to work/school within 3 years from the onset of chronic graft-<i>versus</i>-host disease (HR 2.54; 95% CI: 1.1-5.7, <i>P</i>=0.02), and the haplorelated group trended similarly (HR 2.38; 95% CI: 1.0-5.9, <i>P</i>=0.06). Cord blood recipients were more likely to discontinue immunosuppression than were recipients of unrelated single HLA-allele mismatched peripheral blood (HR 3.96; 95% CI: 1.9-8.4, <i>P</i>=0.0003), similarly to the haplorelated group (HR 4.93; 95% CI: 2.2-11.1, <i>P</i>=0.0001). Progression-free survival and non-relapse mortality did not differ between groups grafted from different types of donors. Our observations that, compared to recipients of unrelated single HLA-allele mismatched peripheral blood, recipients of cord blood and haplorelated grafts less often developed disability related to chronic graft-<i>versus</i>-host disease, and were more likely to resume work/school, should help better counseling of pre-hematopoietic cell transplant candidates.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2024-02-15T12:10:34.159Z","creation":"2019-07-30T07:01:36Z"},"accession":"S-EPMC6442956","cross_references":{"pubmed":["30442722"],"doi":["10.3324/haematol.2018.202754"]}}