{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harris B"],"funding":["University of North Carolina","NIAAA NIH HHS","North Carolina Central University"],"pagination":["45-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6443509"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["80"],"pubmed_abstract":["Previous studies have demonstrated that acute alcohol intoxication significantly impairs lung immune responses, which can lead to the tissue being undefended from microbial infection and resulting disease. Data suggest that acute intoxication presents an axis where simultaneously suppressing early pro-inflammatory cytokines while inducing anti-inflammatory signals contributes to alcohol-dependent immune suppression in the lung, and thus undeterred microbial replication. Interestingly, alcoholics and those with alcohol use disorder present with increased pneumonia and acute respiratory diseases (ARDs), suggesting a more active priming of inflammatory responses in the lungs. There is current research evaluating the acute effects of binge ethanol consumption on adolescents, which is of grave "],"journal":["Alcohol (Fayetteville, N.Y.)"],"pubmed_title":["Alcohol-dependent pulmonary inflammation: A role for HMGB-1."],"pmcid":["PMC6443509"],"funding_grant_id":["U54 AA019765"],"pubmed_authors":["Harris B","Willoughby T","Mcalister A","Sivaraman V"],"additional_accession":[]},"is_claimable":false,"name":"Alcohol-dependent pulmonary inflammation: A role for HMGB-1.","description":"Previous studies have demonstrated that acute alcohol intoxication significantly impairs lung immune responses, which can lead to the tissue being undefended from microbial infection and resulting disease. Data suggest that acute intoxication presents an axis where simultaneously suppressing early pro-inflammatory cytokines while inducing anti-inflammatory signals contributes to alcohol-dependent immune suppression in the lung, and thus undeterred microbial replication. Interestingly, alcoholics and those with alcohol use disorder present with increased pneumonia and acute respiratory diseases (ARDs), suggesting a more active priming of inflammatory responses in the lungs. There is current research evaluating the acute effects of binge ethanol consumption on adolescents, which is of grave ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2025-04-29T10:35:39.22Z","creation":"2020-11-03T08:01:30Z"},"accession":"S-EPMC6443509","cross_references":{"pubmed":["30287211"],"doi":["10.1016/j.alcohol.2018.09.008"]}}