{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bouley J"],"funding":["NICHD NIH HHS","NCATS NIH HHS","FDA HHS","NINDS NIH HHS"],"pagination":["1008-1017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6444888"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(7)"],"pubmed_abstract":["Cortical spreading depression (CSD) has been described after moderate-to-severe traumatic brain injury (TBI). It is uncertain, however, whether CSD occurs after mild, concussive TBI and whether it relates to brain pathology and functional outcome. Male C57BL6/J mice (n = 62) were subjected to closed head TBI with a 25 g weight (n = 11), 50 g weight (n = 45), or sham injury (n = 6). Laser Doppler flowmetry and optical intrinsic signal imaging were used to determine cerebral blood flow dynamics after concussive CSD. Functional deficits were assessed at baseline, 2 h, 24 h, and 48 h. TUNEL and Prussian blue staining were used to determine cell death and presence of cerebral microbleeds at 48 h. No CSD was observed in mice subjected to a 25 g weight drop whereas 58.9% of mice subjected to a 50"],"journal":["Journal of neurotrauma"],"pubmed_title":["Cortical Spreading Depression Denotes Concussion Injury."],"pmcid":["PMC6444888"],"funding_grant_id":["K08 NS091499","KL2 TR002542","R01 NS102969","R01 NS088689","P50 HD060848","P01 NS055104","UL1 TR002541","R25 NS065743","U54 HD060848","R01 FD004127"],"pubmed_authors":["Henninger N","Ayata C","Chung DY","Bouley J","Brown RH"],"additional_accession":[]},"is_claimable":false,"name":"Cortical Spreading Depression Denotes Concussion Injury.","description":"Cortical spreading depression (CSD) has been described after moderate-to-severe traumatic brain injury (TBI). It is uncertain, however, whether CSD occurs after mild, concussive TBI and whether it relates to brain pathology and functional outcome. Male C57BL6/J mice (n = 62) were subjected to closed head TBI with a 25 g weight (n = 11), 50 g weight (n = 45), or sham injury (n = 6). Laser Doppler flowmetry and optical intrinsic signal imaging were used to determine cerebral blood flow dynamics after concussive CSD. Functional deficits were assessed at baseline, 2 h, 24 h, and 48 h. TUNEL and Prussian blue staining were used to determine cell death and presence of cerebral microbleeds at 48 h. No CSD was observed in mice subjected to a 25 g weight drop whereas 58.9% of mice subjected to a 50","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2025-04-26T14:04:12.625Z","creation":"2025-02-18T22:56:57.059Z"},"accession":"S-EPMC6444888","cross_references":{"pubmed":["29999455"],"doi":["10.1089/neu.2018.5844"]}}