{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kimura S"],"funding":["JSPS"],"pagination":["831-846"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6446867"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["216(4)"],"pubmed_abstract":["Microfold (M) cells residing in the follicle-associated epithelium (FAE) of the gut-associated lymphoid tissue are specialized for antigen uptake to initiate mucosal immune responses. The molecular machinery and biological significance of M cell differentiation, however, remain to be fully elucidated. Here, we demonstrate that Sox8, a member of the SRY-related HMG box transcription factor family, is specifically expressed by M cells in the intestinal epithelium. The expression of Sox8 requires activation of RANKL-RelB signaling. Chromatin immunoprecipitation and luciferase assays revealed that Sox8 directly binds the promoter region of Gp2 to increase Gp2 expression, which is the hallmark of functionally mature M cells. Furthermore, genetic deletion of Sox8 causes a marked decrease in the "],"journal":["The Journal of experimental medicine"],"pubmed_title":["Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice."],"pmcid":["PMC6446867"],"funding_grant_id":["JP16H06598","JP16J09413","JP25460261","JP17H04089","JP25293114","JP16K08457"],"pubmed_authors":["Obata Y","Takahashi D","Kimura S","Kobayashi N","Mutoh M","Sato S","Nakamura Y","Kato N","Fujiki R","Nakagawa T","Kanaya T","Iwanaga T","Kaisho T","Ohno H","Hase K"],"additional_accession":[]},"is_claimable":false,"name":"Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice.","description":"Microfold (M) cells residing in the follicle-associated epithelium (FAE) of the gut-associated lymphoid tissue are specialized for antigen uptake to initiate mucosal immune responses. The molecular machinery and biological significance of M cell differentiation, however, remain to be fully elucidated. Here, we demonstrate that Sox8, a member of the SRY-related HMG box transcription factor family, is specifically expressed by M cells in the intestinal epithelium. The expression of Sox8 requires activation of RANKL-RelB signaling. Chromatin immunoprecipitation and luciferase assays revealed that Sox8 directly binds the promoter region of Gp2 to increase Gp2 expression, which is the hallmark of functionally mature M cells. Furthermore, genetic deletion of Sox8 causes a marked decrease in the ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2025-05-18T10:47:07.099Z","creation":"2025-05-18T10:47:07.099Z"},"accession":"S-EPMC6446867","cross_references":{"pubmed":["30877171"],"doi":["10.1084/jem.20181604"]}}