{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["Ushikoshi-Nakayama R"],"pubmed_abstract":["A randomized, double-blind, placebo-controlled, parallel-group comparative clinical study was conducted to examine the effects of ubiquinol (the reduced form of Coenzyme Q10) on secretion of saliva. This interventional study enrolled 40 subjects aged 65 years or younger who were healthy, but noted slight dryness of the mouth. Subjects were randomized with stratification according to gender and age to ingestion of gummy candy containing 50 mg of ubiquinol or placebo twice daily for 8 weeks. At the end of study, along with a significant increase of the CoQ10 level in saliva (p = 0.025*, d = 0.65), there was a significant increase of the saliva flow rate (p = 0.048*, d = 0.66) in the ubiquinol candy group (n = 18; 47.4±6.2 years; 6 men and 12 women) compared to the placebo group (n = 20; 52.2"],"journal":["PloS one"],"pagination":["e0214495"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6447281"],"repository":["biostudies-literature"],"pubmed_title":["Effect of gummy candy containing ubiquinol on secretion of saliva: A randomized, double-blind, placebo-controlled parallel-group comparative study and an in vitro study."],"pmcid":["PMC6447281"],"pubmed_authors":["Kaneko M","Ito Y","Saito I","Ushikoshi-Nakayama R","Sugano T","Yamazaki T","Ryo K","Matsumoto N"],"additional_accession":[]},"is_claimable":false,"name":"Effect of gummy candy containing ubiquinol on secretion of saliva: A randomized, double-blind, placebo-controlled parallel-group comparative study and an in vitro study.","description":"A randomized, double-blind, placebo-controlled, parallel-group comparative clinical study was conducted to examine the effects of ubiquinol (the reduced form of Coenzyme Q10) on secretion of saliva. This interventional study enrolled 40 subjects aged 65 years or younger who were healthy, but noted slight dryness of the mouth. Subjects were randomized with stratification according to gender and age to ingestion of gummy candy containing 50 mg of ubiquinol or placebo twice daily for 8 weeks. At the end of study, along with a significant increase of the CoQ10 level in saliva (p = 0.025*, d = 0.65), there was a significant increase of the saliva flow rate (p = 0.048*, d = 0.66) in the ubiquinol candy group (n = 18; 47.4±6.2 years; 6 men and 12 women) compared to the placebo group (n = 20; 52.2","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-20T03:21:28.495Z","creation":"2019-06-06T21:05:46Z"},"accession":"S-EPMC6447281","cross_references":{"pubmed":["30943227"],"doi":["10.1371/journal.pone.0214495"]}}