{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ferreira I"],"funding":["Steno Diabetes Center Copenhagen (SDCC)","Per S. Henriksen Foundation","Aase and Ejnar Danielsen Foundation","Danish Diabetes Association","Poul and Erna Sehested Hansen Foundation"],"pagination":["231-241"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6448953"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(1)"],"pubmed_abstract":["<h4>Aims/hypothesis</h4>Vascular inflammation and endothelial dysfunction are thought to contribute to arterial stiffening and hypertension. This study aims to test this hypothesis with longitudinal data in the context of type 1 diabetes.<h4>Methods</h4>We investigated, in an inception cohort of 277 individuals with type 1 diabetes, the course, tracking and temporal inter-relationships of BP, specifically pulse pressure (a marker of arterial stiffening) and hypertension, and the following biomarkers of systemic and vascular inflammation/endothelial dysfunction: C-reactive protein (CRP), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin). These biomarkers and other risk factors were measured at ba"],"journal":["Diabetologia"],"pubmed_title":["Biomarkers of inflammation and endothelial dysfunction as predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 year life-course study in an inception cohort."],"pmcid":["PMC6448953"],"funding_grant_id":["SDCC 3.A Complications"],"pubmed_authors":["Parving HH","Rossing P","Schalkwijk CG","Ferreira I","Hovind P","Stehouwer CDA"],"additional_accession":[]},"is_claimable":false,"name":"Biomarkers of inflammation and endothelial dysfunction as predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 year life-course study in an inception cohort.","description":"<h4>Aims/hypothesis</h4>Vascular inflammation and endothelial dysfunction are thought to contribute to arterial stiffening and hypertension. This study aims to test this hypothesis with longitudinal data in the context of type 1 diabetes.<h4>Methods</h4>We investigated, in an inception cohort of 277 individuals with type 1 diabetes, the course, tracking and temporal inter-relationships of BP, specifically pulse pressure (a marker of arterial stiffening) and hypertension, and the following biomarkers of systemic and vascular inflammation/endothelial dysfunction: C-reactive protein (CRP), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin). These biomarkers and other risk factors were measured at ba","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2026-05-07T03:25:39.425Z","creation":"2026-04-07T22:34:16.348Z"},"accession":"S-EPMC6448953","cross_references":{"pubmed":["29101422"],"doi":["10.1007/s00125-017-4470-5"]}}