biostudies-literatureFerreira ISteno Diabetes Center Copenhagen (SDCC)Per S. Henriksen FoundationAase and Ejnar Danielsen FoundationDanish Diabetes AssociationPoul and Erna Sehested Hansen Foundation231-241https://www.ebi.ac.uk/biostudies/studies/S-EPMC6448953biostudies-literatureUnknown61(1)<h4>Aims/hypothesis</h4>Vascular inflammation and endothelial dysfunction are thought to contribute to arterial stiffening and hypertension. This study aims to test this hypothesis with longitudinal data in the context of type 1 diabetes.<h4>Methods</h4>We investigated, in an inception cohort of 277 individuals with type 1 diabetes, the course, tracking and temporal inter-relationships of BP, specifically pulse pressure (a marker of arterial stiffening) and hypertension, and the following biomarkers of systemic and vascular inflammation/endothelial dysfunction: C-reactive protein (CRP), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin). These biomarkers and other risk factors were measured at baDiabetologiaBiomarkers of inflammation and endothelial dysfunction as predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 year life-course study in an inception cohort.PMC6448953SDCC 3.A ComplicationsParving HHRossing PSchalkwijk CGFerreira IHovind PStehouwer CDAfalseBiomarkers of inflammation and endothelial dysfunction as predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 year life-course study in an inception cohort.<h4>Aims/hypothesis</h4>Vascular inflammation and endothelial dysfunction are thought to contribute to arterial stiffening and hypertension. This study aims to test this hypothesis with longitudinal data in the context of type 1 diabetes.<h4>Methods</h4>We investigated, in an inception cohort of 277 individuals with type 1 diabetes, the course, tracking and temporal inter-relationships of BP, specifically pulse pressure (a marker of arterial stiffening) and hypertension, and the following biomarkers of systemic and vascular inflammation/endothelial dysfunction: C-reactive protein (CRP), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin). These biomarkers and other risk factors were measured at ba2018-01-01T00:00:00Z2018 Jan2026-05-07T03:25:39.425Z2026-04-07T22:34:16.348ZS-EPMC64489532910142210.1007/s00125-017-4470-5