{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ahnert P"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Zentrum für Lungenforschung"],"pagination":["110"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6450002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>CAP (Community acquired pneumonia) is frequent, with a high mortality rate and a high burden on health care systems. Development of predictive biomarkers, new therapeutic concepts, and epidemiologic research require a valid, reproducible, and quantitative measure describing CAP severity.<h4>Methods</h4>Using time series data of 1532 patients enrolled in the PROGRESS study, we compared putative measures of CAP severity for their utility as an operationalization. Comparison was based on ability to correctly identify patients with an objectively severe state of disease (death or need for intensive care with at least one of the following: substantial respiratory support, treatment with catecholamines, or dialysis). We considered IDSA/ATS minor criteria, CRB-65, CURB-65, Halm"],"journal":["Critical care (London, England)"],"pubmed_title":["Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia - results from the prospective observational PROGRESS study."],"pmcid":["PMC6450002"],"funding_grant_id":["01KI1010I","01KI07111","01KI1010D","01KI07110","01KI07113","82DZLJ19A2","01KI07114"],"pubmed_authors":["Kiehntopf M","Niebank M","Kropf-Sanchen C","Hempel F","Wirtz H","Brunkhorst FM","Bauer M","Wakonigg G","Mikolajewska A","Moeser A","Thiemig D","Hering I","Ahnert P","Hauptmeier B","Wehde D","Horn K","Liebrich A","Hoffmann U","Suttorp N","Keller N","Keller C","Deterding L","Kahnert H","Bloos F","Dmitriev O","Niesen M","Lehmke J","Dickgreber N","Makowski LM","Creutz P","PROGRESS Study Group","Hobler C","Popkirova K","Schott G","Simpfendorfer M","Pluta J","Ludewig K","Angermair S","Plauth M","Flick H","Schaberg T","Volker U","Ramke M","Balke L","Benzke M","Hamberger S","Wagener B","Buchenroth M","Rademache J","Pletz M","Ruf B","Lensch C","Chakraborty T","Unnewehr M","Koch E","Glaser S","Grah C","Muller T","Knuppel W","Rudiger S","Hossain H","Oqueka T","Loffler M","Rupp J","Charite Icu-Teams","Krollmann C","Garcia C","Schwarzenberger F","Schroder B","Pannier J","Mayer B","Pankow W","Druckmiller H","Lies A","Reinhart K","Schelle M","Thomas-Ruddel D","Kolditz M","Hocke A","Shchetynska-Marinova T","Witzenrath M","Held M","Berber A","Scholz M","Arntzen C","Freise J","Schmidt-Schridde P","Kappauf L","Hartung K","Peckelsen C","Bals R","Follmer U","Schaaf B","Spinner T","Kanwar O","Rosenow F","Mayer P"],"additional_accession":[]},"is_claimable":false,"name":"Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia - results from the prospective observational PROGRESS study.","description":"<h4>Background</h4>CAP (Community acquired pneumonia) is frequent, with a high mortality rate and a high burden on health care systems. Development of predictive biomarkers, new therapeutic concepts, and epidemiologic research require a valid, reproducible, and quantitative measure describing CAP severity.<h4>Methods</h4>Using time series data of 1532 patients enrolled in the PROGRESS study, we compared putative measures of CAP severity for their utility as an operationalization. Comparison was based on ability to correctly identify patients with an objectively severe state of disease (death or need for intensive care with at least one of the following: substantial respiratory support, treatment with catecholamines, or dialysis). We considered IDSA/ATS minor criteria, CRB-65, CURB-65, Halm","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-04-29T02:02:53.609Z","creation":"2019-06-06T21:06:52Z"},"accession":"S-EPMC6450002","cross_references":{"pubmed":["30947753"],"doi":["10.1186/s13054-019-2316-x"]}}