{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang N"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","National Institute of Neurological Disorders and Stroke","Eunice Kennedy Shriver National Institute of Child Health and Human Development","National Eye Institute","University of Washington","National Institute of Mental Health","Jane Coffin Childs Memorial Fund for Medical Research","Japan Society for the Promotion of Science"],"pagination":["e42455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6450671"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of this ensheathment are largely unknown. Here, we describe an evolutionarily conserved morphogenetic mechanism for epidermal ensheathment of somatosensory neurites. We found that somatosensory neurons in Drosophila and zebrafish induce formation of epidermal sheaths, which wrap neurites of different types of neurons to different extents. Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at nascent sheaths, followed by a filamentous actin network, and recruitment of junctional proteins that likely form autotypic junctions to seal sheaths. Finally, blocking epidermal sheath formation destabilized dendrite branches and reduced nociceptive sensitivity in Drosophila. Epidermal somatosensory neurite ensheathment is thus a deeply conserved cellular process that contributes to the morphogenesis and function of nociceptive sensory neurons."],"journal":["eLife"],"pubmed_title":["A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites."],"pmcid":["PMC6450671"],"funding_grant_id":["NIMH R01 MH115767","NEI P30EY001730","NICHD K99 HD086271","NIAMS R01 AR064582","Long term fellowship","WRF-Hall fellowship","NINDS R01 NS076614"],"pubmed_authors":["Rosenberg MF","Rasmussen JP","Luedke KP","Sagasti A","Kim HJ","Vaughan JC","Cronan MR","Jiang N","Clanton JA","Parker ED","Parrish JZ"],"additional_accession":[]},"is_claimable":false,"name":"A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites.","description":"Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of this ensheathment are largely unknown. Here, we describe an evolutionarily conserved morphogenetic mechanism for epidermal ensheathment of somatosensory neurites. We found that somatosensory neurons in Drosophila and zebrafish induce formation of epidermal sheaths, which wrap neurites of different types of neurons to different extents. Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at nascent sheaths, followed by a filamentous actin network, and recruitment of junctional proteins that likely form autotypic junctions to seal sheaths. Finally, blocking epidermal sheath formation destabilized dendrite branches and reduced nociceptive sensitivity in Drosophila. Epidermal somatosensory neurite ensheathment is thus a deeply conserved cellular process that contributes to the morphogenesis and function of nociceptive sensory neurons.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-18T20:27:30.412Z","creation":"2019-06-05T16:17:57Z"},"accession":"S-EPMC6450671","cross_references":{"pubmed":["30855229"],"doi":["10.7554/eLife.42455"]}}