biostudies-literaturePulsipher MANational Institute of Allergy and Infectious DiseasesNational Heart, Lung and Blood InstituteNHLBI/National Cancer Institute [NCI]NCINHLBI and NCINHLBI NIH HHSNCI NIH HHSHealth Resources and Services Administration699-711https://www.ebi.ac.uk/biostudies/studies/S-EPMC6453753biostudies-literatureUnknown25(4)The development of reduced-intensity approaches for allogeneic hematopoietic cell transplantation has resulted in growing numbers of older related donors (RDs) of peripheral blood stem cells (PBSCs). The effects of age on donation efficacy, toxicity, and long-term recovery in RDs are poorly understood. To address this we analyzed hematologic variables, pain, donation-related symptoms, and recovery in 1211 PBSC RDs aged 18 to 79 enrolled in the Related Donor Safety Study. RDs aged > 60 had a lower median CD34⁺ level before apheresis compared with younger RDs (age > 60, 59 × 10⁶/L; age 41 to 60, 81 × 10⁶/L; age 18 to 40, 121 × 10⁶/L; P < .001). This resulted in older donors undergoing more apheresis procedures (49% versus 30% ≥ 2 collections, P < .Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow TransplantationEffect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study.PMC6453753UG1 HL069254U24 HL138660N00014-18-1-2045P30 CA008748N00014-17-1-2388N00014-17-1-28501U24HL138660U24 CA076518R01 HL0857072UG1HL0692545U24CA076518Ahmed IAVarni JWBesser RMLogan BRDrexler RJWaller EKHaight AEDuckworth KKiefer DMDelgado DCWeisdorf DJMcCarty JMYanik GASwitzer GEUberti JPRowley SDVusirikala MShaw BEAnderlini PBigelow CHari PNKasow KAPulsipher MAArtz ASBall EDAbdel-Mageed ABolwell BJLongo WSpitzer TRizzo JDTse WTChitphakdithai PShaughnessy PJBroun ERJacobsohn DAMcGuirk JPHorowitz MMLeitman SFHayes-Lattin BMPrasad VKAkard LPMori SBayer RLLitzow MRKobusingye HConfer DLRiches MLShenoy SHahn TESahdev ILazarus HMSchriber JRRybka WBBunin NJLiesveld JLSelby GBNavarro WHLinenberger MJakubowski AAMagalhaes-Silverman MMiller JPDvorak CCfalseEffect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study.The development of reduced-intensity approaches for allogeneic hematopoietic cell transplantation has resulted in growing numbers of older related donors (RDs) of peripheral blood stem cells (PBSCs). The effects of age on donation efficacy, toxicity, and long-term recovery in RDs are poorly understood. To address this we analyzed hematologic variables, pain, donation-related symptoms, and recovery in 1211 PBSC RDs aged 18 to 79 enrolled in the Related Donor Safety Study. RDs aged > 60 had a lower median CD34⁺ level before apheresis compared with younger RDs (age > 60, 59 × 10⁶/L; age 41 to 60, 81 × 10⁶/L; age 18 to 40, 121 × 10⁶/L; P < .001). This resulted in older donors undergoing more apheresis procedures (49% versus 30% ≥ 2 collections, P < .2019-01-01T00:00:00Z2019 Apr2026-04-30T18:55:29.287Z2020-05-22T14:49:01ZS-EPMC64537533042348010.1016/j.bbmt.2018.11.004