{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Heiney K"],"pubmed_abstract":["Understanding neuronal communication is fundamental in neuroscience, but there are few methodologies offering detailed analysis for well-controlled conditions. By interfacing microElectrode arrays with microFluidics (μEF devices), it is possible to compartmentalize neuronal cultures with a specified alignment of axons and microelectrodes. This setup allows the extracellular recording of spike propagation with a high signal-to-noise ratio over the course of several weeks. Addressing these μEF devices, we developed an advanced yet easy-to-use publically available computational tool, μSpikeHunter, which provides a detailed quantification of several communication-related properties such as propagation velocity, conduction failure, spike timings, and coding mechanisms. The combination of μEF de"],"journal":["Scientific reports"],"pagination":["5777"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6453950"],"repository":["biostudies-literature"],"pubmed_title":["µSpikeHunter: An advanced computational tool for the analysis of neuronal communication and action potential propagation in microfluidic platforms."],"pmcid":["PMC6453950"],"pubmed_authors":["Aguiar P","Heiney K","Neto E","Lopes CDF","Lamghari M","Mateus JC"],"additional_accession":[]},"is_claimable":false,"name":"µSpikeHunter: An advanced computational tool for the analysis of neuronal communication and action potential propagation in microfluidic platforms.","description":"Understanding neuronal communication is fundamental in neuroscience, but there are few methodologies offering detailed analysis for well-controlled conditions. By interfacing microElectrode arrays with microFluidics (μEF devices), it is possible to compartmentalize neuronal cultures with a specified alignment of axons and microelectrodes. This setup allows the extracellular recording of spike propagation with a high signal-to-noise ratio over the course of several weeks. Addressing these μEF devices, we developed an advanced yet easy-to-use publically available computational tool, μSpikeHunter, which provides a detailed quantification of several communication-related properties such as propagation velocity, conduction failure, spike timings, and coding mechanisms. The combination of μEF de","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-07-17T00:40:32.559Z","creation":"2025-05-18T11:07:28.995Z"},"accession":"S-EPMC6453950","cross_references":{"pubmed":["30962522"],"doi":["10.1038/s41598-019-42148-3"]}}