{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uchida S"],"funding":["AMED-CREST","Grants-in-Aid for the Scientific Research B","Hiroshi and Aya Irisawa Memorial Promotion Award for Young Physiologists","Grants-in-Aid for the Scientific Research C","Grants-in-Aid for the Scientific Research on Innovative Areas","Grants-in-Aid for the Scientific Research A"],"pagination":["433-451"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6456489"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["69(3)"],"pubmed_abstract":["An organism stems from assemblies of a variety of cells and proteins. This complex system serves as a unit, and it exhibits highly sophisticated functions in response to exogenous stimuli that change over time. The complete sequencing of the entire human genome has allowed researchers to address the enigmas of life and disease at the gene- or molecular-based level. The consequence of such studies is the rapid accumulation of a multitude of data at multiple levels, ranging from molecules to the whole body, that has necessitated the development of entirely new concepts, tools, and methodologies to analyze and integrate these data. This necessity has given birth to systems biology, an advanced theoretical and practical research framework that has totally changed the directions of not only bas"],"journal":["The journal of physiological sciences : JPS"],"pubmed_title":["Integrative and theoretical research on the architecture of a biological system and its disorder."],"pmcid":["PMC6456489"],"funding_grant_id":["16KT0194","15H04678","22136008","18H04062","22136002","15K08231","18gm0810004h"],"pubmed_authors":["Inoue R","Kurachi Y","Honma M","Uchida S","Nin F","Hibino H","Suzuki H","Furutani K","Kariya Y","Kitano H","Tsumoto K","Kurata Y","Abe T","Asai Y"],"additional_accession":[]},"is_claimable":false,"name":"Integrative and theoretical research on the architecture of a biological system and its disorder.","description":"An organism stems from assemblies of a variety of cells and proteins. This complex system serves as a unit, and it exhibits highly sophisticated functions in response to exogenous stimuli that change over time. The complete sequencing of the entire human genome has allowed researchers to address the enigmas of life and disease at the gene- or molecular-based level. The consequence of such studies is the rapid accumulation of a multitude of data at multiple levels, ranging from molecules to the whole body, that has necessitated the development of entirely new concepts, tools, and methodologies to analyze and integrate these data. This necessity has given birth to systems biology, an advanced theoretical and practical research framework that has totally changed the directions of not only bas","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-06-01T01:16:50.62Z","creation":"2025-06-01T01:16:50.62Z"},"accession":"S-EPMC6456489","cross_references":{"pubmed":["30868372"],"doi":["10.1007/s12576-019-00667-8"]}}