biostudies-literatureCastiglioni VCure Huntington’s Disease InitiativeMedical Research CouncilMinistero dell’Istruzione dell’Università e della RicercaNational Institute for Health Research (NIHR)Seventh Framework ProgrammeNIHFondo per gli Investimenti della Ricerca di Base2115-2124https://www.ebi.ac.uk/biostudies/studies/S-EPMC6458905biostudies-literatureUnknown29(5)DACH1 is the human homolog of the Drosophila dachshund gene, which is involved in the development of the eye, nervous system, and limbs in the fly. Here, we systematically investigate DACH1 expression patterns during human neurodevelopment, from 5 to 21 postconceptional weeks. By immunodetection analysis, we found that DACH1 is highly expressed in the proliferating neuroprogenitors of the developing cortical ventricular and subventricular regions, while it is absent in the more differentiated cortical plate. Single-cell global transcriptional analysis revealed that DACH1 is specifically enriched in neuroepithelial and ventricular radial glia cells of the developing human neocortex. Moreover, we describe a previously unreported DACH1 expression in the human striatum, in particular in the stCerebral cortex (New York, N.Y. : 1991)Dynamic and Cell-Specific DACH1 Expression in Human Neocortical and Striatal Development.PMC6458905RBFR10A01SNF-SI-0616-10011MC_PC_12009MH106934MH110926A-4529602278NS0956542229432010JMMZLY_001Castiglioni VMartino GIennaco ROnorati MBocchi VDSestan NMuzio LVuono RFaedo ALi ZBulfamante GPBarker RACattaneo EfalseDynamic and Cell-Specific DACH1 Expression in Human Neocortical and Striatal Development.DACH1 is the human homolog of the Drosophila dachshund gene, which is involved in the development of the eye, nervous system, and limbs in the fly. Here, we systematically investigate DACH1 expression patterns during human neurodevelopment, from 5 to 21 postconceptional weeks. By immunodetection analysis, we found that DACH1 is highly expressed in the proliferating neuroprogenitors of the developing cortical ventricular and subventricular regions, while it is absent in the more differentiated cortical plate. Single-cell global transcriptional analysis revealed that DACH1 is specifically enriched in neuroepithelial and ventricular radial glia cells of the developing human neocortex. Moreover, we describe a previously unreported DACH1 expression in the human striatum, in particular in the st2019-01-01T00:00:00Z2019 May2025-04-04T07:57:50.88Z2020-05-22T18:47:29ZS-EPMC64589052968834410.1093/cercor/bhy092