biostudies-literatureMesquita ECNIAID NIH HHS319https://www.ebi.ac.uk/biostudies/studies/S-EPMC6460818biostudies-literatureUnknown19(1)<h4>Background</h4>The identification and management of cardiovascular risk factors became a major clinical issue among HIV-infected individuals in the post-cART era. As in the past decades the link between acute infections and cardiovascular diseases became clear in the general population, we sorted to investigate the role of severe infections on incident cardiovascular diseases (CVDs) among HIV-infected individuals.<h4>Methods</h4>HIV-infected individuals aged ≥18 years, with no history of CVD were followed from January 2000 to December 2013 until the occurrence of the first CVD event, death or end of study, whichever occurred first. To explore the effect of severe infections on the incidence of CVD we used extended Cox regression models and stratified post-hospitalization follow-up timeBMC infectious diseasesSevere infection increases cardiovascular risk among HIV-infected individuals.PMC6460818UM1 AI069476Amancio RTVeloso VBozza FALuz PCoelho LEGrinsztejn BMesquita ECfalseSevere infection increases cardiovascular risk among HIV-infected individuals.<h4>Background</h4>The identification and management of cardiovascular risk factors became a major clinical issue among HIV-infected individuals in the post-cART era. As in the past decades the link between acute infections and cardiovascular diseases became clear in the general population, we sorted to investigate the role of severe infections on incident cardiovascular diseases (CVDs) among HIV-infected individuals.<h4>Methods</h4>HIV-infected individuals aged ≥18 years, with no history of CVD were followed from January 2000 to December 2013 until the occurrence of the first CVD event, death or end of study, whichever occurred first. To explore the effect of severe infections on the incidence of CVD we used extended Cox regression models and stratified post-hospitalization follow-up time2019-01-01T00:00:00Z2019 Apr2025-04-26T23:08:36.629Z2019-06-06T22:55:36ZS-EPMC64608183097509210.1186/s12879-019-3894-6