biostudies-literatureUnknown9Xiao YNovel inhibitors are urgently needed for use as targeted therapies to improve the overall survival (OS) of patients with ovarian cancer. Here, we show that cell division cycle 25B (CDC25B) is over-expressed in ovarian tumors and associated with poor patient prognosis. All previously reported CDC25B inhibitors have been identified by their ability to reversibly inhibit the catalytic dephosphorylation activity of CDC25B <i>in vitro</i>; however, none of these compounds have entered clinical trials for ovarian cancer therapy. In this study, we synthesized a novel small molecule compound, WG-391D, that potently down-regulates CDC25B expression without affecting its catalytic dephosphorylation activity. The inhibition of CDC25B by WG-391D is irreversible, and WG-391D should therefore exhibit poFrontiers in oncology236https://www.ebi.ac.uk/biostudies/studies/S-EPMC6463794biostudies-literatureInhibition of CDC25B With WG-391D Impedes the Tumorigenesis of Ovarian Cancer.PMC6463794Jin WWang BWang CXiao YZhang RGao DJiang PZhan PLi YDu BGu FChen YZhang CYu YSong YfalseInhibition of CDC25B With WG-391D Impedes the Tumorigenesis of Ovarian Cancer.Novel inhibitors are urgently needed for use as targeted therapies to improve the overall survival (OS) of patients with ovarian cancer. Here, we show that cell division cycle 25B (CDC25B) is over-expressed in ovarian tumors and associated with poor patient prognosis. All previously reported CDC25B inhibitors have been identified by their ability to reversibly inhibit the catalytic dephosphorylation activity of CDC25B <i>in vitro</i>; however, none of these compounds have entered clinical trials for ovarian cancer therapy. In this study, we synthesized a novel small molecule compound, WG-391D, that potently down-regulates CDC25B expression without affecting its catalytic dephosphorylation activity. The inhibition of CDC25B by WG-391D is irreversible, and WG-391D should therefore exhibit po2019-01-01T00:00:00Z20192026-04-15T15:13:27.565Z2019-06-06T22:55:50ZS-EPMC64637943102484110.3389/fonc.2019.00236