{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Khalesi M"],"pubmed_abstract":["The synthesis of a novel category of pseudo-peptides via intramolecular Ugi reaction of levulinic acid (4-oxopentanoic acid), aromatic and aliphatic amines, and amino acid-based isocyanides is reported. Levulinic acid was applied as a bifunctional substrate containing both carbonyl and acid moieties suitable for the Ugi reaction. This article provides a facile and convenient one-pot procedure for the synthesis of peptide-like heterocyclic molecules containing 2-pyrrolidone (γ-lactam), amide and ester functional groups with good to excellent yields."],"journal":["Beilstein journal of organic chemistry"],"pagination":["852-857"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6466677"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides."],"pmcid":["PMC6466677"],"pubmed_authors":["Khalesi M","Ziyaei Halimehjani A","Martens J"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides.","description":"The synthesis of a novel category of pseudo-peptides via intramolecular Ugi reaction of levulinic acid (4-oxopentanoic acid), aromatic and aliphatic amines, and amino acid-based isocyanides is reported. Levulinic acid was applied as a bifunctional substrate containing both carbonyl and acid moieties suitable for the Ugi reaction. This article provides a facile and convenient one-pot procedure for the synthesis of peptide-like heterocyclic molecules containing 2-pyrrolidone (γ-lactam), amide and ester functional groups with good to excellent yields.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2024-02-15T10:32:48.588Z","creation":"2019-06-06T22:56:21Z"},"accession":"S-EPMC6466677","cross_references":{"pubmed":["31019577"],"doi":["10.3762/bjoc.15.82"]}}