{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Navari R"],"pubmed_abstract":["An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4<i>H</i>-chromen-4-one, malononitrile, primary amines in the presence of Et<sub>3</sub>N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach."],"journal":["Beilstein journal of organic chemistry"],"pagination":["874-880"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6466694"],"repository":["biostudies-literature"],"pubmed_title":["Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction."],"pmcid":["PMC6466694"],"pubmed_authors":["Mirzaie S","Hamdan F","Balalaie S","Rominger F","Mehrparvar S","Navari R","Darvish F"],"additional_accession":[]},"is_claimable":false,"name":"Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction.","description":"An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4<i>H</i>-chromen-4-one, malononitrile, primary amines in the presence of Et<sub>3</sub>N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-19T11:08:07.679Z","creation":"2019-06-06T22:56:20Z"},"accession":"S-EPMC6466694","cross_references":{"pubmed":["31019580"],"doi":["10.3762/bjoc.15.85"]}}