biostudies-literatureUnknown15Navari RAn efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4<i>H</i>-chromen-4-one, malononitrile, primary amines in the presence of Et₃N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.Beilstein journal of organic chemistry874-880https://www.ebi.ac.uk/biostudies/studies/S-EPMC6466694biostudies-literatureEfficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction.PMC6466694Mirzaie SHamdan FBalalaie SRominger FMehrparvar SNavari RDarvish FfalseEfficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction.An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4<i>H</i>-chromen-4-one, malononitrile, primary amines in the presence of Et₃N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.2019-01-01T00:00:00Z20192025-04-19T11:08:07.679Z2019-06-06T22:56:20ZS-EPMC64666943101958010.3762/bjoc.15.85