biostudies-literature00390Unknown15Wang Y(-)-Isoguaiene was prepared from (<i>S</i>)-citronellal in only 9-10 steps with good overall yields. Either a trienyne or a dienediyne metathesis and highly diastereoselective organocatalytic Michael additions of aldehydes derived from (<i>S</i>)-citronellal served as the key transformations.Beilstein journal of organic chemistry858-862https://www.ebi.ac.uk/biostudies/studies/S-EPMC6466796biostudies-literatureAn efficient synthesis of the guaiane sesquiterpene (-)-isoguaiene by domino metathesis.PMC6466796Metz PDarweesh AFWang YZimdars P39falseAn efficient synthesis of the guaiane sesquiterpene (-)-isoguaiene by domino metathesis.(-)-Isoguaiene was prepared from (<i>S</i>)-citronellal in only 9-10 steps with good overall yields. Either a trienyne or a dienediyne metathesis and highly diastereoselective organocatalytic Michael additions of aldehydes derived from (<i>S</i>)-citronellal served as the key transformations.2019-01-01T00:00:00Z20192024-02-15T10:32:53.266Z2019-06-06T22:56:20ZS-EPMC64667963101957810.3762/bjoc.15.83