{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Karunakaran U"],"funding":["KNU","NRF","National Research Foundation of Korea","Kyungpook National University"],"pagination":["192-205"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6470101"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(2)"],"pubmed_abstract":["Background
Chronic hyperglycemia has deleterious effects on pancreatic β-cell function and turnover. Recent studies support the view that cyclin-dependent kinase 5 (CDK5) plays a role in β-cell failure under hyperglycemic conditions. However, little is known about how CDK5 impair β-cell function. Myricetin, a natural flavonoid, has therapeutic potential for the treatment of type 2 diabetes mellitus. In this study, we examined the effect of myricetin on high glucose (HG)-induced β-cell apoptosis and explored the relationship between myricetin and CDK5.Methods
To address this question, we subjected INS-1 cells and isolated rat islets to HG conditions (30 mM) in the presence or absence of myricetin. Docking studies were conducted to validate the interaction between myricetin a"],"journal":["Diabetes & metabolism journal"],"pubmed_title":["Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5."],"pmcid":["PMC6470101"],"funding_grant_id":["2016R1E1A2020567"],"pubmed_authors":["Moon JS","Jeon JH","Kim ND","Park KG","Leem J","Elumalai S","Won KC","Karunakaran U","Lee IK"],"additional_accession":[]},"is_claimable":false,"name":"Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5.","description":"Background
Chronic hyperglycemia has deleterious effects on pancreatic β-cell function and turnover. Recent studies support the view that cyclin-dependent kinase 5 (CDK5) plays a role in β-cell failure under hyperglycemic conditions. However, little is known about how CDK5 impair β-cell function. Myricetin, a natural flavonoid, has therapeutic potential for the treatment of type 2 diabetes mellitus. In this study, we examined the effect of myricetin on high glucose (HG)-induced β-cell apoptosis and explored the relationship between myricetin and CDK5.Methods
To address this question, we subjected INS-1 cells and isolated rat islets to HG conditions (30 mM) in the presence or absence of myricetin. Docking studies were conducted to validate the interaction between myricetin a","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-07-17T01:36:08.078Z","creation":"2019-06-06T22:56:58Z"},"accession":"S-EPMC6470101","cross_references":{"pubmed":["30688049"],"doi":["10.4093/dmj.2018.0052"]}}