{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rucins M"],"funding":["EuroNanoMed-II"],"pagination":["E115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6470589"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(3)"],"pubmed_abstract":["The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising nanocarriers for DNA delivery. We have revealed that the mean diameter of freshly prepared nanoparticles varied from 58 to 513 nm, depending upon the 4-(N-alkylpyridinium)-1,4-DHP structure. Additional"],"journal":["Pharmaceutics"],"pubmed_title":["Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines."],"pmcid":["PMC6470589"],"funding_grant_id":["ES RTD/2017/31"],"pubmed_authors":["Tirzite D","Gulbe A","Pajuste K","Jackevica L","Liepins J","Plotniece A","Kibilda S","Petrichenko O","Domracheva I","Sobolev A","Plotniece M","Dimitrijevs P","Smits K","Rucins M"],"additional_accession":[]},"is_claimable":false,"name":"Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines.","description":"The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising nanocarriers for DNA delivery. We have revealed that the mean diameter of freshly prepared nanoparticles varied from 58 to 513 nm, depending upon the 4-(N-alkylpyridinium)-1,4-DHP structure. Additional","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-26T23:14:13.455Z","creation":"2019-06-06T22:57:12Z"},"accession":"S-EPMC6470589","cross_references":{"pubmed":["30871041"],"doi":["10.3390/pharmaceutics11030115"]}}