biostudies-literature00600Park SCNational Research Foundation of KoreaE176https://www.ebi.ac.uk/biostudies/studies/S-EPMC6470642biostudies-literatureUnknown17(3)Six new phenalenone derivatives (1⁻6), along with five known compounds (7⁻11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.Marine drugsPhenalenones from a Marine-Derived Fungus Penicillium Sp.PMC64706422018R1A4A1021703Kim DLee SKPark SCJulianti EOh KBShin AJNoh MAhn SOh DC60falsePhenalenones from a Marine-Derived Fungus Penicillium Sp.Six new phenalenone derivatives (1⁻6), along with five known compounds (7⁻11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.2019-01-01T00:00:00Z2019 Mar2024-11-15T02:45:43.852Z2019-06-06T22:57:14ZS-EPMC64706423088991610.3390/md17030176