{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang L"],"funding":["China Scholarship Council","European Research Council"],"pagination":["1994-2003"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6470887"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2019(10)"],"pubmed_abstract":["Pre-activation based glycosylations have become a very powerful tool in the assembly of oligosaccharides and the use of nucleophilic additives allows for the in situ generation of reactive intermediates with tailored reactivity. We here use a glycosylation strategy that is based on the use of per-benzylated imidate building blocks for the fully stereoselective construction of a spacer equipped <i>Aspergillus fumigatus</i> α-1,3-octaglucan. We have used the trimethylsilyl iodide (TMSI)-triphenylphosphine oxide (Ph<sub>3</sub>P=O) for the stereoselective installation of an azidopropanol spacer and triflic acid (TfOH)-dimethyl formamide (DMF) enabled glycosylations for the coupling reactions with the secondary glucosyl C-3-alcohols. An operationally simple in situ activation coupling procedur"],"journal":["European journal of organic chemistry"],"pubmed_title":["Reagent Controlled Stereoselective Assembly of α-(1,3)-Glucans."],"pmcid":["PMC6470887"],"funding_grant_id":["726072"],"pubmed_authors":["Overkleeft HS","Codee JDC","Wang L","van der Marel GA"],"additional_accession":[]},"is_claimable":false,"name":"Reagent Controlled Stereoselective Assembly of α-(1,3)-Glucans.","description":"Pre-activation based glycosylations have become a very powerful tool in the assembly of oligosaccharides and the use of nucleophilic additives allows for the in situ generation of reactive intermediates with tailored reactivity. We here use a glycosylation strategy that is based on the use of per-benzylated imidate building blocks for the fully stereoselective construction of a spacer equipped <i>Aspergillus fumigatus</i> α-1,3-octaglucan. We have used the trimethylsilyl iodide (TMSI)-triphenylphosphine oxide (Ph<sub>3</sub>P=O) for the stereoselective installation of an azidopropanol spacer and triflic acid (TfOH)-dimethyl formamide (DMF) enabled glycosylations for the coupling reactions with the secondary glucosyl C-3-alcohols. An operationally simple in situ activation coupling procedur","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-26T23:07:22.156Z","creation":"2019-06-06T22:46:55Z"},"accession":"S-EPMC6470887","cross_references":{"pubmed":["31007571"],"doi":["10.1002/ejoc.201800894"]}}