biostudies-literatureWang LChina Scholarship CouncilEuropean Research Council1994-2003https://www.ebi.ac.uk/biostudies/studies/S-EPMC6470887biostudies-literatureUnknown2019(10)Pre-activation based glycosylations have become a very powerful tool in the assembly of oligosaccharides and the use of nucleophilic additives allows for the in situ generation of reactive intermediates with tailored reactivity. We here use a glycosylation strategy that is based on the use of per-benzylated imidate building blocks for the fully stereoselective construction of a spacer equipped <i>Aspergillus fumigatus</i> α-1,3-octaglucan. We have used the trimethylsilyl iodide (TMSI)-triphenylphosphine oxide (Ph₃P=O) for the stereoselective installation of an azidopropanol spacer and triflic acid (TfOH)-dimethyl formamide (DMF) enabled glycosylations for the coupling reactions with the secondary glucosyl C-3-alcohols. An operationally simple in situ activation coupling procedurEuropean journal of organic chemistryReagent Controlled Stereoselective Assembly of α-(1,3)-Glucans.PMC6470887726072Overkleeft HSCodee JDCWang Lvan der Marel GAfalseReagent Controlled Stereoselective Assembly of α-(1,3)-Glucans.Pre-activation based glycosylations have become a very powerful tool in the assembly of oligosaccharides and the use of nucleophilic additives allows for the in situ generation of reactive intermediates with tailored reactivity. We here use a glycosylation strategy that is based on the use of per-benzylated imidate building blocks for the fully stereoselective construction of a spacer equipped <i>Aspergillus fumigatus</i> α-1,3-octaglucan. We have used the trimethylsilyl iodide (TMSI)-triphenylphosphine oxide (Ph₃P=O) for the stereoselective installation of an azidopropanol spacer and triflic acid (TfOH)-dimethyl formamide (DMF) enabled glycosylations for the coupling reactions with the secondary glucosyl C-3-alcohols. An operationally simple in situ activation coupling procedur2019-01-01T00:00:00Z2019 Mar2025-04-26T23:07:22.156Z2019-06-06T22:46:55ZS-EPMC64708873100757110.1002/ejoc.201800894