{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Silva AF"],"funding":["Fundação para a Ciência e a Tecnologia","ERAB: The European Foundation for Alcohol Research"],"pagination":["E583"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6472147"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(3)"],"pubmed_abstract":["Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to modulate the pathophysiology of experimental PAH. Male Wistar rats with monocrotaline (MCT)-induced PAH (60 mg/kg) were allowed to drink either xanthohumol-fortified beer (MCT + FB) or 5.2% ethanol (MCT + SHAM) for a period 4 weeks. At the end of the protocol, cardiopulmonary exercise testing and hemodynamic recordings were performed, followed by sample collection for further analysi"],"journal":["Nutrients"],"pubmed_title":["Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition."],"pmcid":["PMC6472147"],"funding_grant_id":["EA 14 23","OE/SAU/UI0038/2014; UID/BIM/04293/2013, UID/IC/00051/2013, SFRH/BPD/90010/2012"],"pubmed_authors":["Leite-Moreira A","Silva AF","Santos MF","Sousa-Nunes F","Ferreira-Pinto MJ","Tiago Guimaraes J","Henriques-Coelho T","Negrao R","Duarte D","Moreira-Goncalves D","Faria-Costa G","Rodrigues I"],"additional_accession":[]},"is_claimable":false,"name":"Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition.","description":"Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to modulate the pathophysiology of experimental PAH. Male Wistar rats with monocrotaline (MCT)-induced PAH (60 mg/kg) were allowed to drink either xanthohumol-fortified beer (MCT + FB) or 5.2% ethanol (MCT + SHAM) for a period 4 weeks. At the end of the protocol, cardiopulmonary exercise testing and hemodynamic recordings were performed, followed by sample collection for further analysi","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2026-07-17T00:54:25.502Z","creation":"2019-06-06T22:57:59Z"},"accession":"S-EPMC6472147","cross_references":{"pubmed":["30857304"],"doi":["10.3390/nu11030583"]}}