biostudies-literatureSilva AFFundação para a Ciência e a TecnologiaERAB: The European Foundation for Alcohol ResearchE583https://www.ebi.ac.uk/biostudies/studies/S-EPMC6472147biostudies-literatureUnknown11(3)Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to modulate the pathophysiology of experimental PAH. Male Wistar rats with monocrotaline (MCT)-induced PAH (60 mg/kg) were allowed to drink either xanthohumol-fortified beer (MCT + FB) or 5.2% ethanol (MCT + SHAM) for a period 4 weeks. At the end of the protocol, cardiopulmonary exercise testing and hemodynamic recordings were performed, followed by sample collection for further analysiNutrientsAnti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition.PMC6472147EA 14 23OE/SAU/UI0038/2014; UID/BIM/04293/2013, UID/IC/00051/2013, SFRH/BPD/90010/2012Leite-Moreira ASilva AFSantos MFSousa-Nunes FFerreira-Pinto MJTiago Guimaraes JHenriques-Coelho TNegrao RDuarte DMoreira-Goncalves DFaria-Costa GRodrigues IfalseAnti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition.Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to modulate the pathophysiology of experimental PAH. Male Wistar rats with monocrotaline (MCT)-induced PAH (60 mg/kg) were allowed to drink either xanthohumol-fortified beer (MCT + FB) or 5.2% ethanol (MCT + SHAM) for a period 4 weeks. At the end of the protocol, cardiopulmonary exercise testing and hemodynamic recordings were performed, followed by sample collection for further analysi2019-01-01T00:00:00Z2019 Mar2026-07-17T00:54:25.502Z2019-06-06T22:57:59ZS-EPMC64721473085730410.3390/nu11030583