{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen W"],"funding":["Swiss National Science Foundation","Wellcome Trust"],"pagination":["1809"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6472429"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revealed that KFZPs contribute to a wide variety of other biological processes. Using murine and human in vitro and in vivo models, we demonstrate here that one poorly studied KZFP, ZFP30, promotes adipogenesis by directly targeting and activating a retrotransposon-derived Pparg2 enhancer. Through mechanistic studies, we further show that ZFP30 recruits the co-regulator KRAB-associated protein 1 (KAP1), which, surprisingly, acts as a ZFP30 co-activator in this adipogenic context. Our findings provide an understanding of both adipogenic and KZF"],"journal":["Nature communications"],"pubmed_title":["ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer."],"pmcid":["PMC6472429"],"funding_grant_id":["206688/Z/17/Z","138323"],"pubmed_authors":["Dainese R","Gubelmann C","Duc J","Deplancke B","Wolfrum C","Schwalie PC","Russeil J","Delessa T","Trono D","Imbeault M","Raghav SK","Chen W","Pankevich EV","Jang SM","Cassano M"],"additional_accession":[]},"is_claimable":false,"name":"ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer.","description":"Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revealed that KFZPs contribute to a wide variety of other biological processes. Using murine and human in vitro and in vivo models, we demonstrate here that one poorly studied KZFP, ZFP30, promotes adipogenesis by directly targeting and activating a retrotransposon-derived Pparg2 enhancer. Through mechanistic studies, we further show that ZFP30 recruits the co-regulator KRAB-associated protein 1 (KAP1), which, surprisingly, acts as a ZFP30 co-activator in this adipogenic context. Our findings provide an understanding of both adipogenic and KZF","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-07-17T01:39:23.736Z","creation":"2019-06-06T21:12:13Z"},"accession":"S-EPMC6472429","cross_references":{"pubmed":["31000713"],"doi":["10.1038/s41467-019-09803-9"]}}