biostudies-literatureDu Hfundamental research funds for the central universities5201790https://www.ebi.ac.uk/biostudies/studies/S-EPMC6475574biostudies-literatureUnknown2019Rabbit hemorrhagic disease (RHD) is an acute, high fatal contagious disease induced by rabbit hemorrhagic disease virus (RHDV) with acute severe hepatic injury and causes huge economic loss worldwide. In order to develop an effective and reliable drug to treat this disease in clinic, a prescription formulated with baicalin, linarin, icariin, and notoginsenoside R1 (BLIN) according to the theory of syndrome differentiation and treatment in traditional Chinese veterinary medicine was applied to investigate its curative effects against RHD <i>in vivo</i>. The preliminary study results showed that BLIN prescription exerted good curative effect on RHD therapy. To further validate the curative effect and to investigate the possible related curative mechanisms of this drug, the survival rates, thBioMed research internationalEvaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease <i>In Vivo</i>.PMC6475574Y0201700441201303040KYYJ2018032014030513157255731772784Ming KLiu JHu YWang DHe MDu HZhang SWang JYuan WQiao MWu YfalseEvaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease <i>In Vivo</i>.Rabbit hemorrhagic disease (RHD) is an acute, high fatal contagious disease induced by rabbit hemorrhagic disease virus (RHDV) with acute severe hepatic injury and causes huge economic loss worldwide. In order to develop an effective and reliable drug to treat this disease in clinic, a prescription formulated with baicalin, linarin, icariin, and notoginsenoside R1 (BLIN) according to the theory of syndrome differentiation and treatment in traditional Chinese veterinary medicine was applied to investigate its curative effects against RHD <i>in vivo</i>. The preliminary study results showed that BLIN prescription exerted good curative effect on RHD therapy. To further validate the curative effect and to investigate the possible related curative mechanisms of this drug, the survival rates, th2019-01-01T00:00:00Z20192025-05-29T22:09:45.786Z2025-05-29T22:09:45.786ZS-EPMC64755743108082010.1155/2019/5201790