biostudies-literatureLi WU.S. Environmental Protection AgencyNIA NIH HHSNIEHS NIH HHSNHLBI NIH HHSNIEHSFramingham Heart StudyNational Institute of General Medical SciencesNIGMS NIH HHS36-43https://www.ebi.ac.uk/biostudies/studies/S-EPMC6478022biostudies-literatureUnknown171<h4>Background</h4>Short-term exposure to air pollution has been associated with cardiovascular events, potentially by promoting endothelial cell activation and inflammation. A few large-scale studies have examined the associations and have had mixed results.<h4>Methods</h4>We included 3820 non-current smoking participants (mean age 56 years, 54% women) from the Framingham Offspring cohort examinations 7 (1998-2001) and 8 (2005-2008), and Third Generation cohort examination 1 (2002-2005), who lived within 50 km of a central monitoring station. We calculated the 1- to 7-day moving averages of fine particulate matter (PM_2.5), black carbon (BC), sulfate (SO₄^2-), nitrogen oxides (NO_x), and ozone before examination visits. We used linear mixed effect models for P-selectin, monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1, lipoprotein-associated phospholipase A2 activity and mass, and osteoprotegerin that were measured up to twice, and linear regression models for CD40 ligand and interleukin-18 that were measured once, adjusting for demographics, life style and clinical factors, socioeconomic position, time, and meteorology.<h4>Results</h4>We found negative associations of PM_2.5 and BC with P-selectin, of ozone with MCP-1, and of SO₄^2- and NO_x with osteoprotegerin. At the 5-day moving average, a 5 µg/m³ higher PM_2.5 was associated with 1.6% (95% CI: - 2.8, - 0.3) lower levels of P-selectin; a 10 ppb higher ozone was associated with 1.7% (95% CI: - 3.2, - 0.1) lower levels of MCP-1; and a 20 ppb higher NO_x was associated with 2.0% (95% CI: - 3.6, - 0.4) lower levels of osteoprotegerin.<h4>Conclusions</h4>We did not find evidence of positive associations between short-term air pollution exposure and endothelial cell activation. On the contrary, short-term exposure to higher levels of ambient pollutants were associated with lower levels of P-selectin, MCP-1, and osteoprotegerin in the Framingham Heart Study.Environmental researchShort-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study.PMC6478022R01 AG028321P01 ES009825P20 GM1090361P20GM109036-01A1R01 ES0298462R01 HL092577HHSN268201500001CP30 ES0000021R01 AG028321N01-HC-25195R01 HL076784P50 HL120163R01 HL0925771R01 HL128914N01 HC025195K23 ES026204HHSN268201500001I1R01 HL64753N01HC25195R01 HL128914P01 ES09825RD‐835872‐01Schwartz JDVasan RSGold DRMittleman MALi WRice MBLjungman PLDorans KSCoull BAKoutrakis PKeaney JFWilker EHBenjamin EJfalseShort-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study.<h4>Background</h4>Short-term exposure to air pollution has been associated with cardiovascular events, potentially by promoting endothelial cell activation and inflammation. A few large-scale studies have examined the associations and have had mixed results.<h4>Methods</h4>We included 3820 non-current smoking participants (mean age 56 years, 54% women) from the Framingham Offspring cohort examinations 7 (1998-2001) and 8 (2005-2008), and Third Generation cohort examination 1 (2002-2005), who lived within 50 km of a central monitoring station. We calculated the 1- to 7-day moving averages of fine particulate matter (PM_2.5), black carbon (BC), sulfate (SO₄^2-), nitrogen oxides (NO_x), and ozone before examination visits. We used linear mixed effect models for P-selectin, monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1, lipoprotein-associated phospholipase A2 activity and mass, and osteoprotegerin that were measured up to twice, and linear regression models for CD40 ligand and interleukin-18 that were measured once, adjusting for demographics, life style and clinical factors, socioeconomic position, time, and meteorology.<h4>Results</h4>We found negative associations of PM_2.5 and BC with P-selectin, of ozone with MCP-1, and of SO₄^2- and NO_x with osteoprotegerin. At the 5-day moving average, a 5 µg/m³ higher PM_2.5 was associated with 1.6% (95% CI: - 2.8, - 0.3) lower levels of P-selectin; a 10 ppb higher ozone was associated with 1.7% (95% CI: - 3.2, - 0.1) lower levels of MCP-1; and a 20 ppb higher NO_x was associated with 2.0% (95% CI: - 3.6, - 0.4) lower levels of osteoprotegerin.<h4>Conclusions</h4>We did not find evidence of positive associations between short-term air pollution exposure and endothelial cell activation. On the contrary, short-term exposure to higher levels of ambient pollutants were associated with lower levels of P-selectin, MCP-1, and osteoprotegerin in the Framingham Heart Study.2019-01-01T00:00:00Z2019 Apr2024-02-14T19:51:02.274Z2020-05-22T14:49:49ZS-EPMC64780223065424710.1016/j.envres.2018.10.027