{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu W"],"funding":["National Natural Science Foundation of China","University Science Research Project of Jiangsu Province","Research Start-up Fund of Changshu Institute of Technology","Natural Science Foundation of Jiangsu Province"],"pagination":["E1234"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6480081"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(7)"],"pubmed_abstract":["The efficient, one-pot access to the transamidation of 8-aminoquinoline (8-AQ), notorious for its harsh removal conditions, has been widely employed as an auxiliary in C⁻H functionalization reactions due to its strong directing ability. In this study, the facile and mild Boc protection of the corresponding 8-AQ amide was critical to activate the amide C<sub>(acyl)</sub>⁻N bond by twisting its geometry to lower the amidic resonance energy. Both aryl and alkyl amines proceeded transamidation in one-pot, user-friendly conditions with excellent yields."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["An Efficient, One-Pot Transamidation of 8-Aminoquinoline Amides Activated by Tertiary-Butyloxycarbonyl."],"pmcid":["PMC6480081"],"funding_grant_id":["21602017","16KJB150001","XZ1508","BK20160405"],"pubmed_authors":["Yi J","Li S","Yuan R","Wu W","Xu H"],"additional_accession":[]},"is_claimable":false,"name":"An Efficient, One-Pot Transamidation of 8-Aminoquinoline Amides Activated by Tertiary-Butyloxycarbonyl.","description":"The efficient, one-pot access to the transamidation of 8-aminoquinoline (8-AQ), notorious for its harsh removal conditions, has been widely employed as an auxiliary in C⁻H functionalization reactions due to its strong directing ability. In this study, the facile and mild Boc protection of the corresponding 8-AQ amide was critical to activate the amide C<sub>(acyl)</sub>⁻N bond by twisting its geometry to lower the amidic resonance energy. Both aryl and alkyl amines proceeded transamidation in one-pot, user-friendly conditions with excellent yields.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2026-05-07T03:51:33.35Z","creation":"2019-06-06T23:00:10Z"},"accession":"S-EPMC6480081","cross_references":{"pubmed":["30934862"],"doi":["10.3390/molecules24071234"]}}