biostudies-literaturevan Bilsen JHMStichting voor de Technische WetenschappenMinisterie van Economische ZakenDutch Research Council (NWO)206https://www.ebi.ac.uk/biostudies/studies/S-EPMC6480866biostudies-literatureUnknown20(1)<h4>Background</h4>Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, concerns with regards to safety and long-term efficacy of OIT remain. There is a need to identify biomarkers that predict, monitor and/or evaluate the effects of OIT. Here we present a method to select candidate biomarkers for efficacy and safety assessment of OIT using the computational approaches Bayesian networks (BN) and Topological Data Analysis (TDA).<h4>Results</h4>Data were used from fructo-oligosaccharide diet-supported OIT experiments performed in 3 independent cow's milk allergy (CMA) and 2 independent peanut allergy (PNA) experiments in mice. Bioinformatical approaches were used to understand the data structure. The BN predicted the efficacy of OIT in the CMBMC bioinformaticsA network-based approach for identifying suitable biomarkers for oral immunotherapy of food allergy.PMC6480866Not applicable12652Pieters RHHWagenaar LVerschuren LKnippels LMJvan den Broek TJSmit JJVonk MMvan Bilsen JHMvan Esch BCAMGarssen JfalseA network-based approach for identifying suitable biomarkers for oral immunotherapy of food allergy.<h4>Background</h4>Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, concerns with regards to safety and long-term efficacy of OIT remain. There is a need to identify biomarkers that predict, monitor and/or evaluate the effects of OIT. Here we present a method to select candidate biomarkers for efficacy and safety assessment of OIT using the computational approaches Bayesian networks (BN) and Topological Data Analysis (TDA).<h4>Results</h4>Data were used from fructo-oligosaccharide diet-supported OIT experiments performed in 3 independent cow's milk allergy (CMA) and 2 independent peanut allergy (PNA) experiments in mice. Bioinformatical approaches were used to understand the data structure. The BN predicted the efficacy of OIT in the CM2019-01-01T00:00:00Z2019 Apr2026-07-12T03:23:42.089Z2019-06-06T22:48:39ZS-EPMC64808663101423310.1186/s12859-019-2802-9