{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Chenoll E"],"funding":["Instituto de Salud Carlos III","Ministerio de Educación, Cultura y Deporte"],"pubmed_abstract":["Microbiota is a crucial player in gynecologic health, in which bacteria can shift to a dysbiotic state triggering a pathogenic process. Based on an ecological understanding of the problem, the aim of this study is to select a potential probiotic strain to improve female reproductive tract based on its capacity to initially lower pH and to promote the reduction of pathogenic bacteria. Based on this rationale, strain <i>Lactobacillus rhamnosus</i> BPL005 was initially selected for its capacity to reduce <i>in vitro</i> pH levels and produce organic acids. Subsequently, strain <i>L. rhamnosus</i> BPL005 (CECT 8800) was demonstrated to have a protective role on endometrial infections in an <i>in vitro</i> model of bacterial colonization of primary endometrial epithelial cells with <i>Atopobium"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["114"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6481279"],"repository":["biostudies-literature"],"pubmed_title":["Selection of New Probiotics for Endometrial Health."],"pmcid":["PMC6481279"],"pubmed_authors":["Moreno I","Seco-Durban C","Gonzalez-Monfort M","Ramon D","Silva A","Chenoll E","Vilella F","Sanchez M","Garcia-Grau I","Genoves S","Simon C"],"additional_accession":[]},"is_claimable":false,"name":"Selection of New Probiotics for Endometrial Health.","description":"Microbiota is a crucial player in gynecologic health, in which bacteria can shift to a dysbiotic state triggering a pathogenic process. Based on an ecological understanding of the problem, the aim of this study is to select a potential probiotic strain to improve female reproductive tract based on its capacity to initially lower pH and to promote the reduction of pathogenic bacteria. Based on this rationale, strain <i>Lactobacillus rhamnosus</i> BPL005 was initially selected for its capacity to reduce <i>in vitro</i> pH levels and produce organic acids. Subsequently, strain <i>L. rhamnosus</i> BPL005 (CECT 8800) was demonstrated to have a protective role on endometrial infections in an <i>in vitro</i> model of bacterial colonization of primary endometrial epithelial cells with <i>Atopobium","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-07-12T03:22:10.086Z","creation":"2019-06-06T23:07:37Z"},"accession":"S-EPMC6481279","cross_references":{"pubmed":["31058101"],"doi":["10.3389/fcimb.2019.00114"]}}