biostudies-literatureUnknown9Chenoll EInstituto de Salud Carlos IIIMinisterio de Educación, Cultura y DeporteMicrobiota is a crucial player in gynecologic health, in which bacteria can shift to a dysbiotic state triggering a pathogenic process. Based on an ecological understanding of the problem, the aim of this study is to select a potential probiotic strain to improve female reproductive tract based on its capacity to initially lower pH and to promote the reduction of pathogenic bacteria. Based on this rationale, strain <i>Lactobacillus rhamnosus</i> BPL005 was initially selected for its capacity to reduce <i>in vitro</i> pH levels and produce organic acids. Subsequently, strain <i>L. rhamnosus</i> BPL005 (CECT 8800) was demonstrated to have a protective role on endometrial infections in an <i>in vitro</i> model of bacterial colonization of primary endometrial epithelial cells with <i>AtopobiumFrontiers in cellular and infection microbiology114https://www.ebi.ac.uk/biostudies/studies/S-EPMC6481279biostudies-literatureSelection of New Probiotics for Endometrial Health.PMC6481279Moreno ISeco-Durban CGonzalez-Monfort MRamon DSilva AChenoll EVilella FSanchez MGarcia-Grau IGenoves SSimon CfalseSelection of New Probiotics for Endometrial Health.Microbiota is a crucial player in gynecologic health, in which bacteria can shift to a dysbiotic state triggering a pathogenic process. Based on an ecological understanding of the problem, the aim of this study is to select a potential probiotic strain to improve female reproductive tract based on its capacity to initially lower pH and to promote the reduction of pathogenic bacteria. Based on this rationale, strain <i>Lactobacillus rhamnosus</i> BPL005 was initially selected for its capacity to reduce <i>in vitro</i> pH levels and produce organic acids. Subsequently, strain <i>L. rhamnosus</i> BPL005 (CECT 8800) was demonstrated to have a protective role on endometrial infections in an <i>in vitro</i> model of bacterial colonization of primary endometrial epithelial cells with <i>Atopobium2019-01-01T00:00:00Z20192026-07-12T03:22:10.086Z2019-06-06T23:07:37ZS-EPMC64812793105810110.3389/fcimb.2019.00114